Results 101 to 110 of about 4,509,005 (309)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Novel Integration of Data-Driven Rule Generation and Computational Argumentation for Enhanced Explainable AI

Machine Learning and Knowledge Extraction
Explainable Artificial Intelligence (XAI) is a research area that clarifies AI decision-making processes to build user trust and promote responsible AI. Hence, a key scientific challenge in XAI is the development of methods that generate transparent and ...
Lucas Rizzo, Damiano Verda, Serena Berretta, Luca Longo   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Perception of Lower Extremity Loads in Stroke Survivors [PDF]

, 2015
Objective: This study aimed to improve our understanding of static and dynamic lower extremity sensory perception and the impact of sensory impairments on the control of walking in stroke survivors. Methods: Using a custom, real-time unloading system, we
Chu, Virginia W., Hornby, T. George, Schmit, Brian D.   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Remaining Available Energy Prediction for Energy Storage Batteries Based on Interpretable Generalized Additive Neural Network

Batteries
Precise estimation of the remaining available energy in batteries is not only key to improving energy management efficiency, but also serves as a critical safeguard for ensuring the safe operation of battery systems.
Ji Qi, Pengrui Li, Yifan Dong, Zhicheng Fu, Zhanguo Wang, Yong Yi, Jie Tian   +6 more
doaj   +1 more source

Material Fatigue Testing System [PDF]

, 1973
A system for cyclicly applying a varying load to a material under test is described. It includes a load sensor which senses the magnitude of load being applied to a material, and, upon sensing a selected magnitude of loading, causes the load to be ...
Gilley, P. J.
core   +1 more source

Optimal Net-Load Balancing in Smart Grids with High PV Penetration

, 2018
Mitigating Supply-Demand mismatch is critical for smooth power grid operation. Traditionally, load curtailment techniques such as Demand Response (DR) have been used for this purpose.
Aman Saima, Aman Saima, Kuppannagari Sanmukh R, Roos JG   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source