Results 141 to 150 of about 2,490,428 (309)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Multidisciplinary Design Optimization of Low Wind Speed Wind Turbine

open access: yesKongzhi Yu Xinxi Jishu, 2013
It discusses the relationship between characteristics of wind resource and aerodynamics, structural dynamics, structure, control performance, power performance of wind turbine.
WANG Dian   +3 more
doaj  

Load-displacement curves of the two infilled specimens.

open access: yes
Load-displacement curves of the two infilled specimens.
Sang-Hyun Ji (18114847)   +3 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Non-intrusive load monitoring using prior models of general appliance types

open access: yes, 2012
Non-intrusive appliance load monitoring is the process of disaggregating a household's total electricity consumption into its contributing appliances. In this paper we propose an approach by which individual appliances can be iteratively separated from ...
Parson, Oliver   +3 more
core   +1 more source

ROLE OF STRUCTURE IS IN THE PROCESS OF FERRITIC-PEARLITIC STEEL EROSION

open access: yesNauka ta progres transportu, 2010
The results of study of influence of structure on mechanical properties and behavior of ferrite-perlite steels under the action of contact loads are presented.
O. A. Kuzin   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluation of quality indicators contacting the surface of the tribological system «Wheel – Rail»

open access: yesNauka ta progres transportu, 2013
Purpose. Modern ideas about the contact interaction of bodies in friction are based on models that take into account the geometric parameters of the surface layers constituting tribosystems.
I.O. Vakulenko   +2 more
doaj  

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