Results 71 to 80 of about 4,189,131 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluating Vacuum and Steam Heat to Eliminate Pinewood Nematodes in Naturally Infested Whole Pine Logs

Journal of Nematology
Pinewood nematodes threaten forest health and continue to interfere with international trade because they can be spread around the globe via nematode-infested wood.
Eisenback J. D., Chen Z., White M.
doaj   +1 more source

Mathematical modeling of the roller-rope coupling operation in misalignment conditions

Қарағанды университетінің хабаршысы. Математика сериясы, 2018
The article deals with the results of construction and mathematical modeling of rope - roller coupling in condition of radial misalignment. As a result of modeling, the operation of coupling is revealed in the presence of misalignment of the shafts ...
V.А. Protsenko, М.V. Babiy, V.А. Nastasenko   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The friction behavior and wear mechanism of RV reducer gear steel (20CrMo) subjected to three different heat treatment processes from −20 °C to 100 °C

Journal of Materials Research and Technology
The gear friction pairs in RV reducer always withstand a broad range of temperature, sliding velocity and heavy load. In the research, three types of heat treatment methods (carburizing + quenching, nitrocarburizing and high concentration ...
Jian Guan, Daqi Wu, Liuming Zhang, Gang Wang, Wenjie Chen, Wenjie Lin, Hui Zhao, Pengpeng Bai, Yu Tian, Wei Song   +9 more
doaj   +1 more source

RIDL: Rogue In-Flight Data Load

IEEE Symposium on Security and Privacy, 2019
We present Rogue In-flight Data Load (RIDL), a new class of speculative unprivileged and constrained attacks to leak arbitrary data across address spaces and privilege boundaries (e.g., process, kernel, SGX, and even CPU-internal operations). Our reverse
S. V. Schaik, Alyssa Milburn, Sebastian Österlund, Pietro Frigo, G. Maisuradze, Kaveh Razavi, H. Bos, Cristiano Giuffrida   +7 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

SSA-BiLSTM Model-Based SOH Estimation for Lithium-Ion Batteries

Energies
The State of Health (SOH) of a battery is an important indicator for measuring the performance degradation of batteries. In view of the deficiencies of existing SOH estimation methods in feature processing and model accuracy, this paper conducts research
Yizeng Wu, Bo Rao, Jie Tian, Jinqiao Du, Jiuchun Jiang   +4 more
doaj   +1 more source