Results 101 to 110 of about 45,882 (260)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Implementation of Internet Network Load Balancing at the Faculty of Computer Science UNUSIDA Using the ECMP Method

open access: yesJournal of Electrical Engineering and Computer Sciences
A stable internet speed is essential in supporting worker and student task completion. Slow internet connectivity can become a persistent hindrance if it occurs continuously. Previous research indicates that conventional load balancing methods still have
Nida Aulina, Mochammad Machlul Alamin
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Energy Aware Controller Load Balancing Based on Multi-Agent Deep Reinforcement Learning for Software-Defined Internet of Things

open access: yesJournal of Computer Networks and Communications
Fluctuations in traffic within the Internet of Things (IoT) can affect the performance of the control plane. It is important to maintain stable control plane performance by load balancing strategies.
C. F. Lv, B. Li, J. Wei
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

ELAB:end-host-based congestion aware load balancing for data center network

open access: yesTongxin xuebao, 2019
A good load balance mechanism is the key to effectively use the network of the data center network.In current production data center,ECMP is the de facto load balancing scheme.However,it has two drawbacks.1) the load balance unit is too coarse-grained,2)
Guo CHEN, Weifeng ZHANG
doaj   +2 more sources

Load Balancing for Response Time

open access: yesJournal of Algorithms, 1995
Summary: A centralized scheduler must assign tasks to servers, processing on-line a sequence of task arrivals and departures. Each task runs for an unknown length of time, but comes with a weight that measures resource utilization per unit time. The response time of a server is the sum of the weights of the tasks assigned to it. The goal is to minimize
openaire   +1 more source

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