Results 61 to 70 of about 392,053 (333)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Application of Load Balancing with the Nth Method on Multiple Gateway Internet Networks

IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2019
The Performance of a Network Is Necessary by the Office of the Special Jayapura Regent in matters related to networking. One of the technological problems to increase connections in the network is to use three ISPs and become microtik as a balanced load.
Rasna Rasna, Ahmad Ashari
doaj   +1 more source

Strong Stability of Nash Equilibria in Load Balancing Games

, 2013
We study strong stability of Nash equilibria in load balancing games of m (m >= 2) identical servers, in which every job chooses one of the m servers and each job wishes to minimize its cost, given by the workload of the server it chooses.
Chen, Bo, Li, Song-Song, Zhang, Yu-Zhong
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Simple Load Balancing for Distributed Hash Tables [PDF]

, 1997
Distributed hash tables have recently become a useful building block for a variety of distributed applications. However, current schemes based upon consistent hashing require both considerable implementation complexity and substantial storage overhead to
Byers, John, Considine, Jeffrey, Mitzenmacher, Michael   +2 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

FALB: a FC protocol link aggregation algorithm

Dianxin kexue, 2021
Link aggregation is a common technology to increase the bandwidth by bundling multiple physical links into a logical link.However, in a switching network based on the fibre channel (FC) protocol, as the forwarding traffic continues to concentrate ...
Zhaohui WANG, Jianliang SHEN, Xia ZHANG, Ting CHEN   +3 more
doaj   +2 more sources

Distributed Load-Balancing Method for CCA Parallel Component Applications

Algorithms
Numerous universities and national laboratories in the United States have collaboratively established a Common Component Architecture (CCA) forum to conduct research on parallel component technology.
Lei Guo, Xin Guo, Feiya Lv
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source