Results 61 to 70 of about 375,588 (279)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Application of Load Balancing with the Nth Method on Multiple Gateway Internet Networks
IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2019 The Performance of a Network Is Necessary by the Office of the Special Jayapura Regent in matters related to networking. One of the technological problems to increase connections in the network is to use three ISPs and become microtik as a balanced load.
Rasna Rasna, Ahmad Ashari
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
FALB: a FC protocol link aggregation algorithm
Dianxin kexue, 2021 Link aggregation is a common technology to increase the bandwidth by bundling multiple physical links into a logical link.However, in a switching network based on the fibre channel (FC) protocol, as the forwarding traffic continues to concentrate ...
Zhaohui WANG +3 more
doaj +2 more sources
Tight Load Balancing via Randomized Local Search
, 2017 We consider the following balls-into-bins process with $n$ bins and $m$ balls: each ball is equipped with a mutually independent exponential clock of rate 1.
Berenbrink, Petra +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Distributed Load-Balancing Method for CCA Parallel Component Applications
AlgorithmsNumerous universities and national laboratories in the United States have collaboratively established a Common Component Architecture (CCA) forum to conduct research on parallel component technology.
Lei Guo, Xin Guo, Feiya Lv
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source