Results 151 to 160 of about 3,943,525 (296)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Geometry-Dependent Tensile Load Capacity and Fracture Characteristics of Steel Wire Ropes: A Finite Element Parametric Study. [PDF]

Materials (Basel)
Xiao J, Li Q, Hu L, Wu S, Lin W, Gu C.
europepmc   +1 more source

Analysis and Modification of Methods for Calculating Axial Load Capacity of High-Strength Steel-Reinforced Concrete Composite Columns. [PDF]

Materials (Basel), 2021
Wang J, Duan Y, Wang Y, Wang X, Liu Q.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Load-carrying capacity of mitered furniture corner joints with dovetail keys under diagonal tension load

, 2012
The goal of this study was to introduce a method for estimating stress analysis as an efficient procedure for evaluating the strength of mitered corner joints in furniture structures.
Maleki, S (15668234), Ebrahimi, G (15668222), Derikvand, M (15668219), Dalvand, M (15668237)   +3 more
core  

Identification of suitable methods for static pile load capacity and recommendation for BNBC 2020. [PDF]

Sci Rep
Bhuiyan S, Haque R, Khan ZH, Mahzuz HMA, Islam S.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Axial Load Capacity Prediction of Concrete-Filled Steel Tubes Using Machine Learning: A Comparative Study. [PDF]

Materials (Basel)
Chen B, He W, Huang L, Shi X.
europepmc   +1 more source

Training Load Capacity, Cumulative Risk, and Bone Stress Injuries: A Narrative Review of a Holistic Approach. [PDF]

Front Sports Act Living, 2021
Hamstra-Wright KL, Huxel Bliven KC, Napier C.   +2 more
europepmc   +1 more source