Results 51 to 60 of about 3,943,525 (296)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of the dimple cross-sectional profile on the behavior of gas parallel slider bearings

Frontiers in Mechanical Engineering
This paper studies the effect of the dimple cross-sectional profile on the behavior of gas parallel slider bearings using the numerical method. The numerical method is performed in MATLAB software.
Xiang Liu, Xuanqi Li, Chunjie Yang, Hongbo Kang, Zhibo Zhai, Yuhao Cui, Wenjie Qi, Binhui Han, Fuxi Liu   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Asymmetric Supply Type Hydrostatic Journal Gas Bearings to Support Large Load Rotors

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Rotating machinerys have problems at bearings to support a rotor such as seismic ACROSS transmitters. The ACROSS ( Accurately Controlled Routinely Operated Signal System ) is a new technical method to detect subtle changes in the physical state of Earth ...
Tomohiko ISE, Hiroshi MIYATAKE, Toshihiko ASAMI   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The numerical study of static and dynamic characteristics of multi-layer protuberant foil bearing

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
Multi-layer protuberant foil bearings uses multi-layers of protuberant foils as the elastic support structure to support the smooth top foil. A numerical model with a computational method is developed in this paper to predict the characteristics of the ...
Yu HOU, Yueqing ZHENG, Shuangtao CHEN, Xiufang LIU, Tianwei LAI   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Greening Geographical Load Balancing [PDF]

, 2011
Energy expenditure has become a significant fraction of data center operating costs. Recently, "geographical load balancing" has been suggested to reduce energy cost by exploiting the electricity price differences across regions.
Liu, Zhenhua
core   +1 more source

Compression behaviour of Q355 steel angles with local defect at bolt holes

Frontiers in Materials
This paper presents experimental and numerical studies on compression behaviour of equal-leg steel angles with bolted connection and subjected to local defect at the bolt hole.
Jinglu Zhang, An He, An He, Yu Liu, Yu Liu, Shao-Bo Kang   +5 more
doaj   +1 more source