Results 61 to 70 of about 375,664 (266)

Influence of couple stress and magnetic fluid on the performance of step slider bearing

International Journal of Applied Mechanics and Engineering
This theoretical investigation delves into the performance of step slider bearings, considering the influence of couple stress and magnetic fluid as the lubricating medium.
Dipali K. Chauhan, JIMIT R. PATEL, G.M. Deheri   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Methodology for determining and controlling the load capacity of integrated circuits

Физика волновых процессов и радиотехнические системы
Background. The relevance of the topic of this work is due to the need to increase the reliability of the quality of determination and control of the load capacity of microcircuits. Aim.
Gennady P. Shopin, Alina A. Denisyuk, Mikhail N. Piganov   +2 more
doaj   +1 more source

Hydrostatic Asymmetric Journal Gas Bearings for Largely Unbalanced Rotors of Seismic ACROSS Transmitters

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
In currently working seismic ACROSS (Accurately Controlled Routinely Operated Signal System) transmitters, an unbalanced rotor with large eccentric mass, which generates elastic waves, is supported by roller bearings.
Tomohiko ISE, Takao TORII, Nobuyoshi MORITA, Shinichi TOGO, Makoto OKANO   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental and Finite Element Analysis of Refill Friction Stir Spot Welding in Dissimilar 6061-T6 and 5052-H321 Aluminum Alloys

Journal of Manufacturing and Materials Processing
This study presents an integrated experimental and numerical investigation of the Refill Friction Stir Spot Welding (RFSSW) process applied to dissimilar aluminum alloys.
Dan Cătălin Bîrsan, Vasile Bașliu
doaj   +1 more source