Results 81 to 90 of about 3,943,525 (296)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Instrumentation and Axial Load Testing of Displacement Piles [PDF]

, 2013
Despite the fact that results of many instrumented pile load tests have been reported in the literature, it is difficult to find well-documented instrumentation procedures that can be used when planning a load testing programme.
Salgado, Rodrigo, Prezzi, Monica, Seo, Hoyoung, Kim, Daehyeon, Bica, Adriano V.D.   +4 more
core   +1 more source

Blinded by the load: attention, awareness and the role of perceptual load. [PDF]

, 2014
What is the relationship between attention and conscious awareness? Awareness sometimes appears to be restricted to the contents of focused attention, yet at other times irrelevant distractors will dominate awareness.
Nikos Konstantinou (3323979), Beck, DM, Konstantinou, N, Konstantinou, Nikos, Beck, Diane M, Lavie, N, Beck, Diane M., Nilli Lavie (3323976), Diane M. Beck (394352), Lavie, Nilli   +9 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Finite element prediction of the ultimate axial load capacity of V-section band clamps [PDF]

, 2009
Band clamps with a flat bottomed V-section are used to connect a pair of circular flanges to provide a joint with significant axial strength. Despite the wide application of Vband clamps, their behaviour is not fully understood and the ultimate axial ...
Barrans, Simon, Muller, Matthias, Barrans, S. M., Muller, M.   +3 more
core   +1 more source

Experimentally Validated Nonlinear Analysis of Bridge Plate Girders with Deformations

Studia Geotechnica et Mechanica, 2015
Comprehensive methodology of numerical nonlinear analysis of the consecutive phases in the structural behaviour of bridge plate girders with deformations is presented.
Kużawa Mieszko, Bień Jan
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Stress correction factor in load capacity estimation standard, JIS B 1759, for plastic gears

Journal of Advanced Mechanical Design, Systems, and Manufacturing
The present study is part of a series aimed at enhancing the reliability of JIS B 1759, ”Estimation of tooth bending strength of cylindrical plastic gears.” This study examined the stress correction factor converting the nominal tooth bending stress into
Ichiro MORIWAKI, Akio UEDA, Takao KOIDE, Morimasa NAKAMURA, Karsten STAHL, Thomas TOBIE   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source