Results 111 to 120 of about 132,191 (309)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Power electronics options for large wind farm integration : VSC-based HVDC transmission [PDF]

, 2006
This paper describes the use of voltage source converter based HVDC transmission (VSC transmission) system for grid integration of large wind farms over long distance.
Xu, Lie, Yao, Liangzhong, Lie Xu, Liangzhong Yao, Sasse, C., Christian Sasse, Xu, L., Yao, L., Sasse, Christian   +8 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploiting SRv6 for Stateless and Per-Connection-Consistent Load Balancing

IEEE Access
This paper proposes a new load-balancing method that supports Per-Connection Consistency (PCC) by leveraging ECMP with standardized routing protocols for operational simplicity.
Ryo Nakamura, Kentaro Ebisawa, Hideaki Hayashi, Tatsuya Fujiwara, Tomoko Okuzawa   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Implementasi Load Balancing pada Cluster Server Berbasis Raspberry Pi Memanfaatkan Algoritma Least Connection [PDF]

Keterbatasan sumber daya dalam implementasi server menjadi salah satu aspek yang perlu diperhatikan. Penggunaan Raspberry Pi, yang merupakan sebuah perangkat dengan ukuran kecil dan dapat digunakan sebagai server fisik dengan konsumsi sumber daya rendah,
Setia Budi, Agung, Primananda, Rakhmadhany, Ghozi Mubarak, Fauzan   +2 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Uji Eksperimental Sambungan Pelat Baja Perantara dengan Sekrup Kunci pada Hubungan Balok-Kolom Kayu Meranti Merah

Siklus: Jurnal Teknik Sipil
Research was conducted by testing the connection of solid red meranti wood beam and column using intermediate steel plate with lag screw as fasteners. There were 3 connection samples tested under monotonic load.
Theresia Agustina, Johannes Adhijoso Tjondro, David Setiawan   +2 more
doaj   +1 more source

Analisis Perbandingan Performa Algoritma Round Robin Dan Least Connection Untuk Load Balancing Pada Software Defined Network [PDF]

, 2017
Perkembangan teknologi internet dimana para penggunanya yang menginginkan layanan yang selalu tersedia setiap saat cenderung semakin meningkat mengikuti perkembangan zaman yang biasanya belum tentu didukung dengan bertambahnya layanan server yang cukup ...
Nugroho, Agung
core