Results 91 to 100 of about 132,191 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Investigation into the Bearing Capacity and Mechanics Behavior of the Diaphragm Connection Form of a Utility Tunnel

Buildings
To investigate the impact of various compartment partition plate connection methods within a shield utility tunnel on the mechanics behavior of the connecting nodes and the overall structural integrity, this study examines and simulates three distinct ...
Yongxing Dai, Yi Zeng, Bolun Shi, Hongbo Li   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Numerical simulation of compression bending bearing property of concrete filled steel tubular support joints

Meitan xuebao
Aiming at the problem that the joints of concrete filled steel tubular support under eccentric compression load in deep roadway are easy to fail as weak parts, the mechanical bearing property of casing connection joints and flange connection joints under
Weiping ZHAO, Yuxiang HE, Guozheng XU, Lin ZHONG, Xiao BAI   +4 more
doaj   +1 more source

Effect of Seismic Loading to Prefabricated Connections

, 2010
Endüstriyel yapıların çoğu prefabrik yapılardır ve yüksek sismik risk altında olan bölgeler üzerine inşa edilmişlerdir. Bu yüzden prefabrik yapılar depreme dayanıklı olmak zorundadır ve bu ancak yapı elemanlarının ve bunların montaj detaylarının uygun olması ile mümkündür.
DOĞAN, Mizam, ÖZBAŞARAN, Hakan, GÜNAYDIN, Ayten   +2 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Mechanical properties of timber-concrete connections with steel tube connectors

Sustainable Structures, 2022
Composite connections are important components of timber-concrete hybrid systems. This work presents a novel shear connector for timber-concrete composite (TCC) connections.
Yingyang Liu, Ao Li, Jixing Cao, Dan Yu, Jilu Zhang   +4 more
doaj   +1 more source

Tensile Load of Three-Menber Connection of Coconut and Bangkirai Lumber [PDF]

, 2003
Although Coconut wood is not known in Peraturan Konstruksi Kayu Indonesia 1961 (PICK1), research on the use Coconut wood as a construction material has been initiated by Morisco et al (1998) and Rofaida (1999).
Perpustakaan UGM, i-lib
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Study the muti-bolt fastening under different load positions in gear rack drilling rig

PLoS ONE, 2023
During the operation of drilling rigs, bolts are subjected to significant loads, rendering bolt groups vulnerable to failure due to uneven load distribution.
Jiangang Wang, Lei Shi, Ding Feng, Paul Tu   +3 more
doaj