Results 71 to 80 of about 132,191 (309)

Distinct patterns of voxel‐ and connection‐based white matter hyperintensity distribution and associated factors in early‐onset and late‐onset Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Introduction The distribution of voxel‐ and connection‐based white matter hyperintensity (WMH) patterns in early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD), as well as factors associated with these patterns, remain unclear.
Hui Hong, Yutong Chen, Weiran Liu, Xiao Luo, Minming Zhang, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Implementasi Load Balancing Dengan Metode PCC (Per Connection Classifier) dan Backup Failover [PDF]

, 2023
Apart from having to take into account system failure factors, scalability security, a good network also takes into account the quality or guarantee of the services provided to users or clients, the network must not only be 100% connected but must also ...
Rochman, Achmad Rizky Fatur
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

STIFFNESS AND STRENTH ANALYSIS OF A LUG JOINT STRUCTURE

Jixie qiangdu, 2018
Lug joint is a kind of structure widely used in missile empennages connection. Aiming at the problem of the lug joints in a static experiment,we built the equal simplified FEA model,and systematically analyzed the influence of bolts distribution ...
WANG CongWei, FANG ZePing, NIU Fei, TIAN WeiFeng, LIANG ZuDian   +4 more
doaj  

Experimental Analysis of Laminated Embedded Steel Insert in Load Bearing Connections

Challenging Glass Conference Proceedings, 2020
Use of glass as a load bearing structural elements has increased significantly in last years. The glass is brittle material, which behaves elastically until brittle failure which occurs suddenly without any warning.
Josef Bajtek
doaj   +1 more source

Implementasi Load Balancing Pada Cloud Computing Dengan Algoritme Improved Weighted Least Connection [PDF]

, 2021
Dewasa ini, Cloud computing banyak diminati karena kemampuannya dalam menyelesaikan berbagai masalah dalam dunia komputasi, salah satunya permasalahan sumber daya komputasi yang terbatas.
Pujangga, Muhammad Denny Chrisna
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Experimental Study of Welded Bar Sleeve Wall Panel Connection under Tensile, Shear, and Flexural Loads

International Journal of Concrete Structures and Materials, 2017
This paper presents an experimental study of a new grouted splice connection for wall panels, called Welded Bar Sleeve (WBS). The connections were made from steel pipes and tested with incremental tensile, shear and flexural loads until failure.
Jen Hua Ling, Ahmad Baharuddin Abd. Rahman, Izni Syahrizal Ibrahim, Zuhairi Abdul Hamid   +3 more
doaj   +1 more source