Results 121 to 130 of about 2,026,189 (303)

Calculation Method and Experimental Investigation of Root Bending Stress in Line Contact Spiral Bevel Gear Pairs

Machines
Compared to spiral bevel gear drives with localized conjugation, line contact spiral bevel gears possess a significantly larger meshing area, theoretically achieving full tooth surface contact and substantially enhancing load capacity.
Shiyu Zuo, Yuehai Sun, Liang Chen, Simin Li, Mingyang Wang   +4 more
doaj   +1 more source

Consideration of load distribution and native soft tissue anatomy when choosing an animal bony model. [PDF]

Ann Transl Med, 2023
Anastasio AT, Grant C, Peairs EM, Fernandez-Moure JS.   +3 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Changes in human calcaneal morphology throughout the Pleistocene-Holocene Levant

Frontiers in Earth Science
The calcaneal morphology changed considerably during human evolution to enable efficient bipedal locomotion. However, little information exists regarding its adaptation to changes in habitual activities following the transition to a sedentary lifestyle ...
Ariana Dann, Ariana Dann, Ariel Pokhojaev, Ariel Pokhojaev, Ariel Pokhojaev, Marie Anton, Guy Yalovitsky, Guy Yalovitsky, Ruth Kallevag-Pelleg, Ruth Kallevag-Pelleg, Ruth Kallevag-Pelleg, Hila May, Hila May   +12 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Load distribution after unilateral condylar fracture with shortening of the ramus: a finite element model study. [PDF]

Head Face Med, 2023
Helmer LML, Klop C, Lobbezoo F, de Lange J, Koolstra JH, Dubois L.   +5 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Impact of implant location on load distribution of implant-assisted removable partial dentures: a review of in vitro model and finite-element analysis studies. [PDF]

Int J Implant Dent, 2023
Ichikawa H, Yoda N, Ogawa T, Iwamoto M, Kawata T, Egusa H, Sasaki K.   +6 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A hybrid optimization approach to evaluating load capacity in distribution networks with new energy and energy storage integration

IET Renewable Power Generation
New energy can enhance the load capacity of the distribution networks, and the addition of energy storage can suppress the fluctuations caused by the uncertainty of new energy, promoting the stable load absorption of the distribution networks. This paper
Longtian Zhang, Delin Wang, Jun Wang, Muhammad Shahid Mastoi, Zelin He, Mannan Hassan   +5 more
doaj   +1 more source