Results 61 to 70 of about 509,208 (268)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A bidirectional m-method for allocating spatial effects of special pile groups
Yantu gongcheng xuebaoThe load distribution from a pile group to a single pile is the key issue in calculation of pile foundations. Aiming at the limitation that the one-way m-method in the Chinese specifications and codes is only applicable to plane action, the formulas are ...
LIAO Lijian 1, SU Wei 1, YANG Xinan 2, WANG Yuquan 1
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Online Power-Aware Deployment and Load Distribution Optimization for Application Server Clusters
IEEE Access, 2019 The energy conservation of application server clusters is a pressing problem. In this paper, we propose an online power-aware deployment and load distribution optimization strategy for application server clusters, whose objective is to minimize the ...
Zhi Xiong +3 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017 Splined joints are commonly used to transmit rotary motion from a shaft to machine elements such as gears. While computationally efficient spline load distribution models have recently been proposed, there is no validated load distribution model of a ...
Michael BENATAR +2 more
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Load distribution in the worm meshing
Journal of Theoretical and Applied Mechanics, 2016 The paper presents a theoretical analysis of deflections of circular and rectangular cantilever plates of an elastically built-in edge. The problem has been solved using the finite difference method. A method of determination of load distribution between two plates being in contact along an arbitrary line has been presented.
openaire +3 more sources
THE LOAD DISTRIBUTION PROBLEM IN A PROCESSOR RING [PDF]
Parallel Algorithms and Applications, 2002 Abstract Given a global picture of the system load and the average load, the load distribution problem is to find a suitable schedule, consisting of the amount of excess load to transfer along every edge, so that the system load can be balanced in minimal time by executing the schedule.
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Energies, 2018 Evaporative cooling is a green, energy-efficient cooling technology adopted in hot and dry regions, which has wider application in the field of air-conditioning systems.
Ji Li +6 more
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source