Results 111 to 120 of about 1,259,177 (299)

Airflow control in fuel cell for vehicles based on stack allowable current

机车电传动, 2022
In order to avoid "oxygen hungry" in fuel cells under the loading condition and improve response speed of fuel cells for vehicles, an fuel cells air-flow control method containing allowable current in stack was proposed.
QI Hongfeng, GUO Ai, CHEN Chao, WANG Yingming, SHI Junjie   +4 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research on dynamic traffic control strategy of IoT cloud service

物联网学报, 2018
Flow control is very important to ensure quality of service in cloud service system.A dynamic two-level flow control strategy was proposed.Using the improved minimum connection number algorithm based on the actual cloud service system,the integrated load
Qineng LING, Yichuan WANG, Jiabing YANG, Kan ZHENG   +3 more
doaj   +2 more sources

The North Carolina Racial Justice Act: An Essay on Substantive and Procedural Fairness in Death Penalty Litigation [PDF]

, 2012
Long term supporting schemes for photovoltaic (PV) system installation have led to accommodating large numbers of PV systems within load pockets in distribution grids.
Vidmar, Neil
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research and application of speed stability of flow stabilizing valve in direct-drive electro-hydraulic servo system

International Journal for Simulation and Multidisciplinary Design Optimization
When the direct-drive electro-hydraulic servo system is used for position control of hydraulic actuators, load unbalance or external disturbances can cause flow imbalance, leading to poor speed stability of the actuator and thus reduced position accuracy.
Shen Huan-huan, Liu Ruo-lan, Li Ge-qiang
doaj   +1 more source

Design of a large span-distributed load flying-wing cargo airplane with laminar flow control [PDF]

A design study was conducted to add laminar flow control to a previously design span-distributed load airplane while maintaining constant range and payload.
Lovell, W. A., Price, J. E., Quartero, C. B., Turriziani, R. V., Washburn, G. F.   +4 more
core   +1 more source