Results 91 to 100 of about 2,043,803 (299)

How much load can my pallet carry?

, 2018
Properly determining the exact load carrying capacity of a pallet is essential to ensure the effectiveness of the supply chain. Multiple testing procedures are published by different organizations and all could be used to estimate the load capacity of ...
Horvath, Laszlo
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Direct and external intensity modulation in OFDM RoF links [PDF]

, 2014
This article is available Open Access to view at: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7158985Radio-over-fiber (RoF) systems comprise light modulation and transmission of millimeter-wave signals over fiber links.
Cosmas, John P., Glover, Ian A., Lazaridis, Pavlos I., Zaharias D. Zaharis, Lazaridis, PI, Prasad, NR, Ian A. Glover, Khwandah, Sinan, Khwandah, SA, Zaharis, ZD, Zaharis, Zaharias D., Cosmas, JP, Glover, Ian, Prasad, Neeli R., John P. Cosmas, Cosmas, John, Glover, IA, Lazaridis, Pavlos, Sinan A. Khwandah, Neeli R. Prasad, Pavlos I. Lazaridis, Prasad, Neeli, Khwandah, Sinan A., Lazaridis, Pavlos I.; id_orcid   +23 more
core   +1 more source

Optimum Mode-Switching Assisted Adaptive Modulation

, 2001
Adaptive modulation techniques combat fading by employing a suitable modulation mode depending on the instantaneous channel conditions for improving the Bit Error Rate (BER) performance or the average through-put.
Choi, B.J., Hanzo, L.
core   +1 more source

Load sensitive control characteristics of a novel two-dimensional pulse width modulated variable mechanism

Advances in Mechanical Engineering
Load sensing technology is a typical hydraulic technology that automatically meets load requirements by adjusting the pressure and flow at the pump outlet.
Wu Jian, Ruan Jian, Ren Yan
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Design of Adaptive Highly Efficient GaN Power Amplifier for Octave-Bandwidth Application and Dynamic Load Modulation

, 2012
This paper presents a novel adaptive power amplifier (PA) architecture for performing dynamic-load-modulation. For the first time, a dynamically-load-modulated PA design that achieves octave bandwidth, high power and high efficiency simultaneously is ...
Peroulis, Dimitrios, Chen, Kenle
core   +1 more source