Results 91 to 100 of about 129,952 (301)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Multidimensional Index Modulation in Wireless Communications

IEEE Access, 2018
In index modulation schemes, information bits are conveyed through indexing of transmission entities, such as antennas, subcarriers, times slots, precoders, subarrays, and radio frequency (RF) mirrors.
Bharath Shamasundar, Sandeep Bhat, Swaroop Jacob, Ananthanarayanan Chockalingam   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Processing of angry voices is modulated by visual load

NeuroImage, 2012
Visual perceptual load has been shown to modulate brain activation to emotional facial expressions. However, it is unknown whether cross-modal effects of visual perceptual load on brain activation to threat-related auditory stimuli also exist. The current fMRI study investigated brain responses to angry and neutral voices while subjects had to solve an
Martin Mothes-Lasch, Wolfgang H. R. Miltner, Thomas Straube   +2 more
openaire   +2 more sources

Dynamic load modulation of high power amplifiers with varactor-based matching networks

, 2009
In this paper, the results of dynamic load modulation on a high power amplifier is shown with experiments. A simple static nonlinear model is used as an inverse model, and by dynamically controlling both the input signal to the power amplifier and the ...
Fager, Christian, Fager, Christian,, Christian Fager, Eriksson, Thomas,, Eriksson, Thomas, Haiying Cao, Soltani Tehrani, Ali, Cao, Haiying,, Mashad Nemati, Hossein, Thomas Eriksson, Hossein Mashad Nemati, Cao, Haiying, Soltani Tehrani, Ali,, Mashad Nemati, Hossein,, Ali Soltani Tehrani   +14 more
core   +1 more source

High Efficiency Power Amplifiers for Modern Mobile Communications: The Load-Modulation Approach [PDF]

, 2017
Modern mobile communication signals require power amplifiers able to maintain very high efficiency in a wide range of output power levels, which is a major issue for classical power amplifier architectures.
Chiara Ramella, Piacibello, Anna, Quaglia, Roberto, Camarchia, Vittorio, Anna Piacibello, Ramella, Chiara, Pirola, Marco, Marco Pirola, Vittorio Camarchia, Roberto Quaglia   +9 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Two-Feeder Dynamic Voltage Restorer for Application in Custom Power Parks

Energies, 2019
The custom power park (CPP) is a concept that has been developed for the purpose of dealing with power quality problems. The CPP is powered by two independent feeders and consists of different types of custom power devices for compensation (dynamic ...
Sergio Constantino Yáñez-Campos, Gustavo Cerda-Villafaña, Jose Merced Lozano-Garcia   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source