Results 91 to 100 of about 3,858,842 (297)
Frontiers in PhysiologyPurposeTo compare the effects of maximum intended velocity (MIV), velocity-loss threshold (VLT), target velocity zone combined with velocity-loss threshold (TVZ+VLT), and traditional percentage-based training (PBT) on explosive performance and sprint ...
Junjie Wang +3 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Acute:chronic workload ratio and load management for team sports: a multilevel meta-analysis
Frontiers in Public HealthObjectiveThe acute:chronic workload ratio (ACWR) has been widely used to monitor training load and injury risk in team-sport athletes. However, its practical utility remains debated because of methodological heterogeneity across load metrics, calculation
Liangbi Ding +14 more
doaj +1 more source
How much load can my pallet carry?
, 2018 Properly determining the exact load carrying capacity of a pallet is essential to ensure the effectiveness of the supply chain. Multiple testing procedures are published by different organizations and all could be used to estimate the load capacity of ...
Horvath, Laszlo
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Functional Morphology and KinesiologyThe purpose of this study was to assess the external load demands in futsal, considering both home and away matches and their outcomes, in order to plan microcycles throughout the season based on the external load of each match.
Héctor Gadea-Uribarri +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Session-RPE for quantifying workload in olympic curling athletes
Frontiers in Sports and Active LivingObjectiveTo investigate the correlation between different workload methods among Olympic curling athletes.Materials and methodsEight curlers were monitored after training during Olympic seasons with three load quantification methods: external load ...
Junqi Wu, Chunlei Li
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source