Results 31 to 40 of about 26,572 (214)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The problem of infinite plate loaded with normal force following a complex trajectory*
Advanced Engineering Research, 2019 Introduction. A method for solving the problem of an infinite plate on an elastic foundation is proposed. The plate is affected by a periodic load in the form of a force following an arbitrary closed path.
A. V. Galaburdin
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Steady-state vibrations of a beam structure under moving horizontal force-analytical approach [PDF]
Archives of Civil EngineeringThe following paper presents a dynamic analysis of a railway superstructure subjected to horizontal moving loads. The superstructure including the substructure was modelled with two infinitely long beams connected by an elastic layer. The structure rests
Magdalena Ataman, Wacław Szczesniak
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
MONITORING DYNAMIC DEFORMATION OF SHUTTLE STEEL SHELVES BY DIGITAL PHOTOGRAPHY [PDF]
Civil Engineering Journal, 2019 Shuttle steel shelves (steel shelves equipped with shuttles) are popular in modern logistics. The safety of shuttle steel shelves is an issue due to the complicated dynamic load that develops when the shuttles are in operation.
Chengxin Yu +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Shock and Vibration, 2019 A piston slap is one of the main vibration sources of the reciprocating machinery. Much work has been done in this field, most of which was based on a constant rotating speed.
Siyuan Liu +3 more
doaj +1 more source
Energies, 2017 The output power and terminal voltage of the fixed speed induction generator fluctuate in the partial load region where the wind speed is below the rated vale, resulting in fluctuations in the grid frequency and voltage.
Kanasottu Anil Naik +1 more
doaj +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source