Results 61 to 70 of about 262,357 (266)
To achieve optimal voltage regulation and energy savings of an AC induction motor operating under constant-torque and variable-working-load conditions, and consider a motor's T-type and Γ-type equivalent circuit, the copper and iron losses of the ...
Zhong Bin, Ma Lili, Dong Hao
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Eskom, South Africa's national power utility, is transitioning from centralised, large‐scale electricity coal generation to a more distributed, small‐scale inverter‐based renewable generation to reduce greenhouse gas emissions.
Dumisani Mtolo +2 more
doaj +1 more source
Stability Methods for Regulated Loads.
Power electronic circuits often regulate load power and present a constant power profile to the utility or other electrical source. These constant power loads (CPLs) therefore exhibit a negative incremental input impedance and pose stability challenges when present in either dc or ac systems. This thesis presents CPL design techniques to mitigate these
openaire +1 more source
Cancellation of load regulation in low drop-out regulators
A method for cancelling load regulation, based on level shifting the reference, is proposed. In this architecture, the load current is monitored, sensed, and used to dynamically adapt the effective value of the reference voltage. The proposed architecture reduced a 2.5% load regulation droop to a mere 0.2%, without compromising system stability.
R.K. Dokania, G.A. Rincón-Mora
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

