Results 71 to 80 of about 278,966 (304)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Numerical Analysis of the Tetrapylon Roman's Triumphal Arch of Tebessa: A Case Study. [PDF]

, 2019
The Tetrapylon  Roman Triumphal Arch or commonly called  'Caracalla Gate', located  in Tebessa City (Northern Algeria), is considered as one of the most distinctive type of arches associated with the ancient Roman's architecture. This historical monument,
ROUILI, Ahmed, TOUAHMIA, Mabrouk
core  

Reliability analysis of distribution systems with photovoltaic generation using a power flow simulator and a parallel Monte Carlo approach [PDF]

, 2016
This paper presents a Monte Carlo approach for reliability assessment of distribution systems with distributed generation using parallel computing. The calculations are carried out with a royalty-free power flow simulator, OpenDSS (Open Distribution ...
Guerra Sánchez, Luis Gerardo, Martínez Velasco, Juan Antonio   +1 more
core   +2 more sources

Utility-Oriented Online Load Restoration Considering Wind Power Penetration [PDF]

IEEE Transactions on Sustainable Energy, 2019
An efficient load recovery of a bulk system with wind power penetration requires careful consideration of uncertainties related to it, as well as on-line data gathered from measurement devices. From the perspective of uncertainties, a novel utility-based decision-making method is proposed in this paper.
Jin Zhao, Hongtao Wang, Yutian Liu, Rasoul Azizipanah-Abarghooee, Vladimir Terzija   +4 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A Stackelberg game-based incentive mechanism and discharge guidance strategy for private electric vehicles for distribution systems load restoration

International Journal of Electrical Power & Energy Systems
Effectively utilizing large-scale Private Electric Vehicles (PREVs) in load restoration can enhance the capability of Distribution System Operators (DSOs) to respond to accidental power outages. However, the challenge remains in incentivizing and guiding
Xihao Wang, Xiaojun Wang, Zhao Liu, Weixin Wang, Qingkai Sun, Aiqiang Pan, Jiaming Dou   +6 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Complementary Symmetry Nanowire Logic Circuits: Experimental Demonstrations and in Silico Optimizations [PDF]

, 2008
Complementary symmetry (CS) Boolean logic utilizes both p- and n-type field-effect transistors (FETs) so that an input logic voltage signal will turn one or more p- or n-type FETs on, while turning an equal number of n- or p-type FETs off.
Heath, James R., Kurtin, Juanita N., Sheriff, Bonnie A., Wang, Dunwei   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Load Balancing with Energy Storage Systems Based on Co-Simulation of Multiple Smart Buildings and Distribution Networks [PDF]

, 2017
In this paper, we present a co-simulation framework that combines two main simulation tools, one that provides detailed multiple building energy simulation ability with Energy-Plus being the core engine, and the other one that is a distribution level ...
Ababei, Cristinel, Duerr, Shaun, Ionel, Dan M.   +2 more
core   +1 more source