Results 71 to 80 of about 280,938 (303)

Materials and techniques of Art Nouveau architecture in Italy and Portugal: a first insight for an European route to consistent restoration [PDF]

, 2009
The results of the investigations on building materials and techniques of Casa Major Pessoa, a typical Art Nouveau construction in Aveiro (Portugal), and two coeval Art Nouveau buildings in Bologna (Italy) are presented as a methodological contribution
Dell’Acqua, A. C., Franzoni, E., Sandrolini, F., Varum, H.   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Stackelberg game-based incentive mechanism and discharge guidance strategy for private electric vehicles for distribution systems load restoration

International Journal of Electrical Power & Energy Systems
Effectively utilizing large-scale Private Electric Vehicles (PREVs) in load restoration can enhance the capability of Distribution System Operators (DSOs) to respond to accidental power outages. However, the challenge remains in incentivizing and guiding
Xihao Wang, Xiaojun Wang, Zhao Liu, Weixin Wang, Qingkai Sun, Aiqiang Pan, Jiaming Dou   +6 more
doaj   +1 more source

Indian River Lagoon surface water improvement and management (SWIM) plan, 2002 update. [PDF]

, 2003
In recognition of the need to place additional emphasis on the restoration, protection, and management of the surface water resources of the state, the Florida Legislature, through the Surface Water Improvement and Management (SWIM) Act of 1987, directed
Brockmeyer, Ron, Gostel, Pat, Sime, Patti, Steward, Joel S., VanArman, Joel, Virnstein, Robert   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fault Recovery Strategy with Net Load Forecasting Using Bayesian Optimized LSTM for Distribution Networks

Entropy
To address the impact of distributed energy resource volatility on distribution network fault restoration, this paper proposes a strategy that incorporates net load forecasting.
Zekai Ding, Yundi Chu
doaj   +1 more source

Fuzzy Decision-Support System for Safeguarding Tangible and Intangible Cultural Heritage [PDF]

, 2019
In the current world economic situation, the maintenance of built heritage has been limited due to a lack of funds and accurate tools for proper management and implementation of these actions.
Macías Bernal, Juan Manuel, Ortiz Calderón, Pilar, Prieto, Andrés José, Silva, Ana   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source