Results 141 to 150 of about 2,512,085 (300)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Load-sharing biomechanics of lumbar fixation and fusion with pedicle subtraction osteotomy. [PDF]

Sci Rep, 2021
La Barbera L, Wilke HJ, Ruspi ML, Palanca M, Liebsch C, Luca A, Brayda-Bruno M, Galbusera F, Cristofolini L.   +8 more
europepmc   +1 more source

How much load can my pallet carry?

, 2018
Properly determining the exact load carrying capacity of a pallet is essential to ensure the effectiveness of the supply chain. Multiple testing procedures are published by different organizations and all could be used to estimate the load capacity of ...
Horvath, Laszlo
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Vertical Bearing Mechanism of Batter Pile Groups under Pile-Cap Restraint and Depth-Dependent Pile Spacing

工程科学与技术
Objective The vertical bearing behavior of batter pile groups is influenced by pile-head boundary conditions and pile-soil-pile interaction, but the combined effects of pile-cap restraint and depth-dependent pile spacing in outward-inclined pile groups ...
ZHAO Shuang, WU Juntao, WANG Kuihua, GAN Gang   +3 more
doaj  

Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors. [PDF]

PLoS Comput Biol, 2022
Sarpangala N, Gopinathan A.
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Simulation Study of Load Sharing of the Herringbone Power Split Gear Train

Jixie chuandong
The load sharing design is a crucial technology that leverages the configuration advantages of the herringbone power split gear train. To improve the load sharing characteristics of the herringbone power split gear train, a static model that accounts for
Zhang Lina, Ning Fenglian, Ding Jintao
doaj  

Dynamic cervical plates: biomechanical evaluation of load sharing and stiffness [PDF]

, 2001
journal articleStudy Design. An in vitro biomechanical study using a simulated cervical corpectomy model to compare the load-sharing properties and stiffnesses of two static and two dynamic cervical plates. Objectives.
Gollogly, Sohrab; Mohr, R. Alexander; Nguyen, Bao-Khang; Bachus, Kent N., Dailey, Andrew T.; Brodke, Darrel S.   +1 more
core