Results 121 to 130 of about 681,097 (293)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Local control of multiple module converters with ratings-based load sharing [PDF]

Multiple module dc-dc converters show promise in meeting the increasing demands on ef- ficiency and performance of energy conversion systems. In order to increase reliability, maintainability, and expandability, a modular approach in converter design ...
Shenoy, Pradeep
core  

Reliability analysis of load sharing systems under unequal load-sharing rule with applications

Communications in Statistics - Theory and Methods
We are examining a setup consisting of several parallel-connected k-out-of-m load sharing systems. The load sharing is modeled using proportional conditional failure rates for component failures and load sharing under the unequal load-sharing rule. We have derived the system reliability for the entire setup.
Sutar, Santosh S., Rajguru, Sukumar V., Patil, Prajakta S., Pawar, Somanath D.   +3 more
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Adaptability of the load sharing between the longissimus and components of the multifidus muscle during isometric trunk extension in healthy individuals. [PDF]

Eur J Appl Physiol, 2023
Tier L, Salomoni SE, Hug F, Besomi M, Hodges PW.   +4 more
europepmc   +1 more source

Thermal elastohydrodynamic lubrication of spur gears [PDF]

An analysis and computer program called TELSGE were developed to predict the variations of dynamic load, surface temperature, and lubricant film thickness along the contacting path during the engagement of a pair of involute spur gears.
Cheng, H. S., Wang, K. L.
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Applying a muscle fatigue model when optimizing load-sharing between muscles for short-duration high-intensity exercise: A preliminary study. [PDF]

Front Physiol, 2023
Michaud F, Frey-Law LA, Lugrís U, Cuadrado L, Figueroa-Rodríguez J, Cuadrado J.   +5 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Effects of geometric individualisation of a human spine model on load sharing: neuro-musculoskeletal simulation reveals significant differences in ligament and muscle contribution. [PDF]

Biomech Model Mechanobiol, 2023
Meszaros-Beller L, Hammer M, Riede JM, Pivonka P, Little JP, Schmitt S.   +5 more
europepmc   +1 more source