Results 111 to 120 of about 681,097 (293)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Effect of intramedullary nail stiffness on load-sharing in tibiotalocalcaneal arthrodesis: A patient-specific finite element study. [PDF]
PLoS One, 2023 Terrill P +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Early Clinical Results of Intervertebral Joint Stabilization by Injectable Load-Sharing Polymers. [PDF]
J Pain Res, 2023 Hedman T, Yu J, Singh H, Deer T.
europepmc +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Advances in Mechanical EngineeringTo research the static load sharing performance of non-orthogonal offset helical (NOH) face gear dual-branch drivetrain, the non-orthogonal offset layout forms of the system are explored, and the meshing phase differences of split-stage and converge ...
Xuezhong Fu +5 more
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Load Sharing in the Femur Using Strut Allografts: A Biomechanical Study. [PDF]
Arthroplast Today, 2022 Sharpe FE +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Jixie chuandong, 2018 The reliability of planetary gear transmission is mainly determined by load-sharing characteristics between the planetary wheels. The study on the load-sharing characteristics of planetary gear train is carried out based on the nonlinear finite element ...
Ji Chaoyue +3 more
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