Results 131 to 140 of about 681,097 (293)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Analysis of the Influence of Error on Load Sharing Characteristic of Planetary Transmission System

Jixie chuandong, 2017
A nonlinear transverse-torsional coupled dynamics model for planetary gear sets is established with considering time-varying meshing stiffness and gear backlash,and the changes of dynamic load sharing characteristics are analyzed when errors and error ...
Zhou Lu, Wu Shijing, Li Jing, Wang Xiaosun, Zhu Weilin   +4 more
doaj  

Preliminary biomechanical cadaver study investigating a new load-sharing knee implant. [PDF]

J Exp Orthop, 2021
Saeidi M, Kelly PA, Netzel C, Scadeng M, Kumar P, Prendergast D, Neitzert T, Ramezani M.   +7 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Gear mesh compliance modeling [PDF]

A computer model has been constructed to simulate the compliance and load sharing in a spur gear mesh. The model adds the effect of rim deflections to previously developed state-of-the-art gear tooth deflection models.
Caldwell, R. J., Lewicki, D. G., Savage, M., Wisor, G. D.   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Load-sharing biomechanics of lumbar fixation and fusion with pedicle subtraction osteotomy. [PDF]

Sci Rep, 2021
La Barbera L, Wilke HJ, Ruspi ML, Palanca M, Liebsch C, Luca A, Brayda-Bruno M, Galbusera F, Cristofolini L.   +8 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Effect of Floating Support Parameters on the Load-Sharing Performance of EDPGS Based on Mathematical Statistical Methods

Machines
The encased differential planetary gear system (EDPGS) allows power to be distributed among multiple output paths, enhancing efficiency and reducing weight. Uniform load distribution ensures stable system operation and prolongs service life.
Xiaoyu Che, Rupeng Zhu
doaj   +1 more source

Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors. [PDF]

PLoS Comput Biol, 2022
Sarpangala N, Gopinathan A.
europepmc   +1 more source