Results 101 to 110 of about 754,695 (298)

Study on the frame load spectrum combining mileage and percentile extrapolation

MATEC Web of Conferences, 2018
In order to get the load spectrum that reflects the actual operation condition of agricultural machinery, this paper proposes to compile the load spectrum of frame by combining the method of load mileage extrapolation and percentile extrapolation.
Song Qingchun, Song Zhenghe, Du Yuefeng
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Fatigue Life Estimation of the Critical Wing Structure in a New-Generation Stol Aircraft

Fatigue of Aircraft Structures
The lower wing section of an aircraft is considered particularly vulnerable to fatigue failure due to the presence of inspection holes, which create stress concentrations and increase local stress in the surrounding material.
Dewa Rando Tungga, Atami M. Ircham, Setiawan Anang, Maulana Fattah, Wafiqni   +4 more
doaj   +1 more source

Load spectrum synthesis and amplitude sequence digitization method of shearer drum cutting coal rock

Meitan xuebao
Shearer working conditions have strong stochastic complex and variable factors, its whole life cycle course of stochastic load spectrum acquisition and discrete sequence processing, as well as the whole domain load spectrum synthesis and digitization is ...
Chunsheng LIU, Shuo CHENG, Chunping REN, Lei WANG, Ruohan LIU, Yanting LIU, Degen LI   +6 more
doaj   +1 more source

Fatigue experience from tests carried out with forged beam and frame structures in the development of the Saab aircraft Viggen [PDF]

A part of the lower side of the main wing at the joint of the main spar with the fuselage frame was investigated. This wing beam area was simulated by a test specimen consisting of a spar boom of AZ 74 forging (7075 aluminum alloy modified with 0.3 ...
Larsson, S. E.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Research of Dynamic Load Spectrum Simulation Method of Hybrid Electric Vehicle Transmission System based on RPC

Jixie chuandong, 2020
In order to evaluate the fatigue durability of the hybrid vehicle driveline， the load simulation test system is used to simulate the dynamic load spectrum of the vehicle on the actual road.
Kaihua Cheng
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

DC-10 composite vertical stabilizer ground test program [PDF]

A review of the structural configuration and ground test program is presented. Particular emphasis is placed on the testing of a full-scale stub box test subcomponent and full span ground test unit.
Palmer, J. M., Jr., Stephens, C. O., Sutton, J. O.   +2 more
core   +1 more source