Results 81 to 90 of about 754,695 (298)

Beam heat load analysis with COLDDIAG: a cold vacuum chamber for diagnostics [PDF]

, 2015
The knowledge of the heat intake from the electron beam is essential to design the cryogenic layout of superconducting insertion devices. With the aim of measuring the beam heat load to a cold bore and understanding the responsible mechanisms, a cold ...
Bartolini, R., Casalbuoni, S., Cox, M. P., Gerstl, S., Grau, A. W., Holubek, T., Jauregui, D. Saez de, Longhi, E. C., MIGLIORATI, Mauro, Rehm, G., Schouten, J. C., SPATARO, BRUNO, Voutta, R., Walker, R. P.   +13 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Modularized Development of a Wheel-Side Electric Drive System Using the Process of Hobbing and Form Grinding

Applied Sciences
The wheel-side electric drive system is a melding of a vehicle powertrain and suspension system, which saves chassis space and can adapt to different models.
Xiaoyu Ding, Wei Wang, Xinbo Chen
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Discussions on some problems of full-scale aircraft fatigue test

Hangkong gongcheng jinzhan
Full-scale aircraft fatigue test is a large, complex and long-lasting ground verification test required by the specification to sustain aircraft structural integrity program and meet airworthiness requirements.
ZHANG Lixin
doaj   +1 more source

Spectral Decay of Time and Frequency Limiting Operator

, 2014
For fixed $c,$ the Prolate Spheroidal Wave Functions (PSWFs) $\psi_{n, c}$ form a basis with remarkable properties for the space of band-limited functions with bandwidth $c$. They have been largely studied and used after the seminal work of D. Slepian, H.
Bonami, Aline, Karoui, Abderrazek
core   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Accelerated Editing Method for Vehicle Durability Fatigue Load Spectrum Based on Wigner-Ville Transform. [PDF]

Sensors (Basel), 2023
Yang Y, Zhang Z, Peng L, Jin J, Wang Q.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Using finite element method in preoperative planning for wrist surgery [PDF]

, 2008
The wrist has a wide variation of 'normal' anatomy, which may explain the discrepancy seen in success rates of some clinical procedures between patients with similar symptoms.
Gislason, M.K., Nash, D.H.
core