Results 61 to 70 of about 196,993 (262)

Spectrum of the axially loaded Timoshenko rod

Acta Mechanica
Abstract The response to excitation in the axially loaded Timoshenko rod is greatly influenced by the type of axial load, which could be compressive or tensile. The results presented in this article have practical applications, particularly when the axial load is compressive, as non-positive eigenvalues indicate possible buckling.
K. A. Hohls, N. F. J. Van Rensburg
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Novel Load Extrapolation Method for Multiple Non-Stationary Loads on the Drill Pipe of a Rotary Rig

Machines
The drill pipe of a rotary rig is subject to the dynamic influence of non-stationary loads, including rotation torque and applied force. In order to address the challenge of simultaneously extrapolating multiple non-stationary loads, a novel ...
Haijin Wang, Zonghai Zhang, Jiguang Zhang, Yuying Shen, Jixin Wang   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Modularized Development of a Wheel-Side Electric Drive System Using the Process of Hobbing and Form Grinding

Applied Sciences
The wheel-side electric drive system is a melding of a vehicle powertrain and suspension system, which saves chassis space and can adapt to different models.
Xiaoyu Ding, Wei Wang, Xinbo Chen
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Discussions on some problems of full-scale aircraft fatigue test

Hangkong gongcheng jinzhan
Full-scale aircraft fatigue test is a large, complex and long-lasting ground verification test required by the specification to sustain aircraft structural integrity program and meet airworthiness requirements.
ZHANG Lixin
doaj   +1 more source

Predictive Current Control Strategy with Imposed Load Current Spectrum

2006 12th International Power Electronics and Motion Control Conference, 2006
This paper presents a modified predictive current control strategy which allows one to have control over the spectrum of the load current. The proposed method uses a model of the system to predict the behavior of the current for each possible voltage vector generated by the inverter.
Cortés, Patricio, Rodríguez, José, Quevedo, Daniel, Silva, Cesar   +3 more
openaire   +6 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Accelerated Editing Method for Vehicle Durability Fatigue Load Spectrum Based on Wigner-Ville Transform. [PDF]

Sensors (Basel), 2023
Yang Y, Zhang Z, Peng L, Jin J, Wang Q.
europepmc   +1 more source