Results 51 to 60 of about 196,993 (262)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Some Comments Concerning the Preparation of and Fatigue Testing of the Aircraft’s Cable-Control System

Fatigue of Aircraft Structures
The currently accepted rules that are applied to the aircraft cable-control systems’ operational use are based on the reactive maintenance idea and the comparative tests, inspections, and diagnostics performed at the mandatory intervals. Fatigue tests of
Brzęczek Józef
doaj   +1 more source

Rain Flow Counting Analysis on Operating Pressure Cycle Characteristics of Gas Pipeline

Shiyou jixie, 2022
The analysis on the operating pressure cycle characteristics of gas pipeline is an important research basis for predicting the fatigue life of the pipeline.
Shuai Jian, Zhang Yi
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Vibration Response Analysis of Metro Vehicle Converter Cabinet Based on Finite Element Method

机车电传动, 2018
The vibration response analysis of metro vehicle converter cabinet was carried out based on FEM software HyperMesh and Virtual.Lab. The vibration acceleration response of converter cabinet lugs was obtained by modal analysis and correction, transfer ...
XIA Liang, DING Jie, WANG Yongsheng, ZENG Yaping, ZANG Xiaobin, LI Zhenpeng   +5 more
doaj  

The Load Cycle Amplitude Model: An Efficient Time-Domain Extrapolation Technique for Non-Stationary Loads in Agricultural Machinery

Agriculture
In traditional time-domain extrapolation methods, the peak over threshold (POT) model is unable to accurately identify large load cycles in the load time history, resulting in distorted extrapolation results, particularly when addressing non-stationary ...
Zihan Yang, Xuke Liu, Zhenghe Song, Hanting Liu   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Establishment and Analysis of Load Spectrum for Bogie Frame of High-Speed Train at 400 km/h Speed Level

Machines
The bogie frame, as one of the most critical load-bearing structures of the Electric Multiple Unit (EMU), is responsible for bearing and transmitting various loads from the car body, wheelsets, and its own installation components.
Guidong Tao, Zhiming Liu, Chengxiang Ji, Guangxue Yang   +3 more
doaj   +1 more source

Research on the vibration test load spectrum for bogie frame-mounted tractor motor based on on-track tests

机车电传动, 2023
Ignoring the effects of high-frequency signals and small-amplitude cycles that contribute little to structural fatigue damage, rainflow counting was performed on the vibration load of traction motors to generate a three-dimensional load spectrum.
LI Guoshun, GUO Lirong, CHEN Can, ZHANG Yichao, ZHANG Hongwei   +4 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source