Results 31 to 40 of about 196,993 (262)

The Definition of the Load Spectrum for SU-22 Fighter-Bomber Full Scale Fatigue Test

Fatigue of Aircraft Structures, 2015
The Su-22 fighter-bomber is a military aircraft used in the Polish Air Force since the mid 1980’s. By the decision of the Polish Ministry of Defense the predicted service life for this type of aircraft will be extended to 3200 flight hours.
Reymer Piotr, Kurdelski Marcin, Leski Andrzej, Jankowski Krzysztof   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An Accelerated Editing Method for Stress Signal on Combine Harvester Chassis Using Wavelet Transform

Sensors
This paper presents a load spectrum acceleration editing method based on wavelet transform. The principle of the method is to decompose the target signal using wavelet transform to obtain high-frequency wavelet components, which are classified and ...
Shengcao Huang, Zihan Yang, Zhenghe Song, Zhiwei Yu, Xiaobo Guo, Du Chen   +5 more
doaj   +1 more source

Extrapolation of Tractor Traction Resistance Load Spectrum and Compilation of Loading Spectrum Based on Optimal Threshold Selection Using a Genetic Algorithm

Agriculture, 2023
To obtain the load spectrum of the traction resistance of the three-point suspension device under tractor-plowing conditions, a load spectrum extrapolation method based on a genetic algorithm optimal threshold selection is proposed.
Meng Yang, Xiaoxu Sun, Xiaoting Deng, Zhixiong Lu, Tao Wang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dynamic Modeling of a Hydraulic Excavator Stick by Introducing Multi-Case Synthesized Load Spectrum for Bench Fatigue Test

Machines, 2022
A multi-case load spectrum compiling method is proposed in this study for dynamic modeling of a hydraulic excavator stick to simplify and accelerate the fatigue bench test.
Penghui Wang, Qingyi Xiang, Grzegorz Królczyk, Pengmin Lu, Binhua Wang, Zhixiong Li   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Fatigue Damage Assessment of a Metro Vehicle Bogie Frame Based on Measured Field Load

Machines
As the operating conditions of metro vehicles become more complex, the fatigue damage of metro bogie frames under actual operating conditions becomes increasingly difficult to evaluate realistically.
Yangmin Wu, Zunsong Ren
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source