Results 81 to 90 of about 1,221,623 (254)
Cluster-Based Load Balancing Algorithms for Grids
, 2011 E-science applications may require huge amounts of data and high processing power where grid infrastructures are very suitable for meeting these requirements. The load distribution in a grid may vary leading to the bottlenecks and overloaded sites.
Dagdeviren, Orhan +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A system-level mathematical model for evaluation of power train performance of load-leveled electric-vehicles [PDF]
The power train performance of load leveled electric vehicles can be compared with that of nonload leveled systems by use of a simple mathematical model. This method of measurement involves a number of parameters including the degree of load leveling and
Leising, C. J., Purohit, G. P.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
EnergiesWith the rapid expansion of 5G base stations, the increasing energy consumption and fluctuations in power grid loads pose significant challenges to both network operators and grid stability.
Nan Zhang +8 more
doaj +1 more source
The bi-composite transition joint [PDF]
, 1972 The application of advanced composite materials to high performance structure frequently results in the desire to fabricate a structure from more than one composite system in order to tailor the composite material capabilities to the design requirements.
Dullea, K. C., Jr.
core +1 more source
Correlation between stick-slip frictional sliding and charge transfer
, 2010 A decade ago, Budakian and Putterman (Phys. Rev. Lett., {\bf 85}, 1000 (2000)) ascribed friction to the formation of bonds arising from contact charging when a gold tip of a surface force apparatus was dragged on polymethylmethacrylate surface.
A. S. Nowick +6 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
, 1974 A heat transfer device is characterized by an hermetically sealed tubular housing including a tubular shell terminating in spaced end plates, and a tubular mesh wick concentrically arranged and operatively supported within said housing.
Kalkbrenner, R. W.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source