Results 141 to 150 of about 1,653,673 (316)

Safe dynamic design of structures. [PDF]

open access: yes, 2000
The Design of structures under dynamic loading is a demanding subject in safety of engineering design since conventional static failure criteria are unable to deal with structures under transient loading.
Moatamedi, Mojtaba, Moatamedi, M.
core  

Performance Indicators Definition during Hydromechanical Transmission Gear Shift

open access: yesМеханика машин, механизмов и материалов, 2011
The microprocessor controller deviсе and mathematical model for control were presented. The performance indicators of mobile machines hydro mechanical transmission are shown to determine during shift road testing or modeling experimental period.
V.N. Basalaev   +4 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Introduction To Special Issue: FuturePlay Selected Papers

open access: yes, 2009
This special issue of Loading… brings together a selection of the most highly reviewed papers from the annual ACM FuturePlay 2008 International Conference on the Future of Game Design and Technology conference that was held in Toronto, Ontario, November ...
Jenson, Jennifer   +2 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Large deformations of thin plates subjected to impulsive loading

open access: yes, 1987
Includes bibliographical references.The dynamic response of structures subjected to blast and impact loading has been obtained relatively simply using rigid-plastic or rigid-viscoplastic material idealisations.
Nurick, Gerald N
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

peak loads

open access: yes, 2010
This concise and clearly focused Dictionary, with contributions by the leading authorities in their fields, brings order and clarity to a topic that can suffer from confusion over terminology and concepts.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Indie Eh? Some Kind of Game Studies.

open access: yes, 2012
This introduction to this special issue of Loading... considers the articles of the issue in the context of game studies’ growing interest in, and implication with, the cultures of independent game development and the ‘indie scene’ in general. ‘Indie’ is
Simon, Bart
core  

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