Results 161 to 170 of about 1,653,673 (316)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Strengenthening of concrete bridges using reinforced sprayed concrete under state and fatigue loading.

open access: yes, 1997
PhDThe Department of Transport's bridge assessment programme has revealed that a significant number of bridges are not strong enough to carry the much heavier commercial axle loads that will soon be applied to UK bridges. To address this problem, this
Dung, Pham-Thanh
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Critical Loading Events for the Assessment of Medium-Span Bridges

open access: yes, 2012
The Sixth International Conference on Computational Structures Technology Prague, Czech Republic 4-6 September 2002This paper describes the simulation of free-flowing traffic across bridges to predict the characteristic values for bridge load effects
O'Brien, Eugene J.   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Sum-rate maximisation comparison using incremental approaches with different constraints

open access: yes, 2009
In this work, the problem of rate maximisation of multichannel systems is considered. Two greedy allocation approaches using power (GPA) and bit (GBA) loading schemes with a slight difference in design constraints that aiming to maximise the overall ...
Al-Hanafy, Waleed, Weiss, S.
core  

Home - About - Disclaimer - Privacy