Results 151 to 160 of about 83,723 (219)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loads and load factors

, 1960
openaire   +1 more source

Loaded: Server Load Balancing for IPv6

International conference on Networking and Services (ICNS'06), 2006
With the next generation Internet protocol IPv6 at the horizon, it is time to think about how applications can migrate to IPv6. Web traffic is currently one of the most important applications in the Internet. The increasing popularity of dynamically generated content on the World Wide Web, has created the need for fast web servers.
Friedrich, Sven, Krahmer, Sebastian, Schneidenbach, Lars, Schnor, Bettina (Prof. Dr.)   +3 more
openaire   +3 more sources

Balanced Loading

Operations Research, 1992
We develop a heuristic for a problem motivated by the loading of aircraft or trucks: pack blocks into a bin so that their center-of-gravity is as close as possible to a target point. Our heuristic either produces good solutions or else signals that none is possible.
Samir V. Amiouny, John J. Bartholdi III, John H. Vande Vate, Jixian Zhang   +3 more
openaire   +1 more source

Loads and load distribution

2022
This chapter has been developed from that authored by Dr M. J. Ryall in the 1st edition published in 2000, much of which remains applicable to bridges today. While permanent dead load and superimposed dead loads are covered, it deals primarily with the intensity and application of the transient loads on bridge structures according to European, British ...
openaire   +1 more source

Distribution transformer loading with deferred loads

2012 IEEE PES Innovative Smart Grid Technologies (ISGT), 2012
Introduction of deferrable loads such as electric vehicles, on the distribution system will have major impact on the electric utility system operations and especially the loading of the distribution transformers. This paper addresses challenges associated with overloading on the distribution transformer and offers new approach to reducing its loading ...
Aleksandar Vukojevic, Nawal Parwal, Christopher Yasko   +2 more
openaire   +1 more source

A unified load generator based on formal load specification and load transformation

Proceedings of the 1st international conference on Performance evaluation methodolgies and tools - valuetools '06, 2006
Optimizing the performance of existing networks often demands realistic and valid load generation tools. As the network loads observed may vary significantly over time, there is a strong need to develop flexible and extensible load generators which can reproduce these loads accurately.
Jing Cong, Bernd E. Wolfinger
openaire   +1 more source