Results 151 to 160 of about 6,457,110 (386)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Determination of stress intensity factors for interface cracks under mixed-mode loading [PDF]

A simple technique was developed using conventional finite element analysis to determine stress intensity factors, K1 and K2, for interface cracks under mixed-mode loading.
Crews, John H., Jr., Naik, Rajiv A.
core   +1 more source

Study on the evolutionary characteristics of strain energy on crack propagation in coal and rock under bending load [PDF]

Yueying Zhang, Dongxiao Zhang, Xufei Gong, Wei Zhang, Lei Zhang   +4 more
openalex   +1 more source

The assessment of correctness of engine adaptation for alternative LPG fueling based on full load engine characteristics of performance [PDF]

, 2014
Dariusz Szpica, J. Czaban
openalex   +1 more source

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

Nature Reviews Rheumatology, 2020
E. Gracey, A. Burssens, I. Cambré, G. Schett, R. Lories, I. McInnes, H. Asahara, D. Elewaut   +7 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Status of off-bottom mariculture in wave-exposed environments. Part 2. Comparative loading and motion of longline designs currently used in exposed commercial farms

Frontiers in Aquaculture
A global inventory of extractive species mariculture in wave-exposed temperate waters shows that the longline is the technology used in more than 99% of the sites (Part 1 of this review).
Marc Gagnon
doaj   +1 more source

Reliability and Acute Changes in the Load–Velocity Profile During Countermovement Jump Exercise Following Different Velocity‐Based Resistance Training Protocols in Recreational Runners [PDF]

Alejandro Pérez‐Castilla, Santiago A. Ruiz‐Alias, Rodrigo Ramírez‐Campillo, Felipe García‐Pinillos, Aitor Marcos‐Blanco   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source