Results 81 to 90 of about 1,653,673 (316)
Constitutive modelling of the behaviour of clays under cyclic loading
, 1989 Includes bibliography.This research work involved the implementation of a constitutive model based on plasticity theory to model the behaviour of a clay under cyclic loading.
Sellers, E J
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells [PDF]
, 2016 Although excessive mechanical stress loading is known to induce articular cartilage degradation, the mechanism underlying this process is unclear.
Ishiguro, Naoki +5 more
core +1 more source
International Journal of NanomedicineXiaoyi Shi,1,* Jingqian Su,1,* Wenting Li,1 Keke Li,2 Xiangjun Chen,1 Wei Hong1 1School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, Yantai, Shandong ...
Shi X, Su J, Li W, Li K, Chen X, Hong W
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Response of thin circular plates to central blast loading
, 1996 Includes bibliographical references.The large ductile deformation response and rupture of thin circular metal plates subjected to central blast loading is investigated using the ABAQUS general purpose finite element code.
Bimha, Richard Ernest
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Internal Phosphorus Loading in Spring Lake: Year 2
, 2004 Experimental and desktop studies were conducted during 2004 to better understand the factors affecting internal phosphorus (P) loading in Spring Lake, Michigan.
Steinman, Dr. Alan +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source