Results 101 to 110 of about 1,895,947 (252)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The Influence of Correclation on the Extreme Traffic Loading of Bridges [PDF]
, 2012 Bridge Maintenance, Safety and Management (IABMAS'10) the Fifth International IABMAS Conference, Philadelphia, USA, 11-15 July 2010Accurate traffic loading models based on measured data are essential for the accurate assessment of existing bridges ...
O'Brien, Eugene J. +2 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Механика машин, механизмов и материалов, 2015 This article finishes publication of results of high-power hydromechanical transmissions investigation. The first and the second parts were published in previous editions of journal. In this part gearboxes with four and more degrees of freedomareanalyzed
Vladimir B. Algin +2 more
doaj
Data Variability in Rheological Measurement of Semi-Solid Foods: Effects of Loading Normal Force
Applied Rheology, 2002 Previous studies involving rheological measurement of semi-solid foods have reported a large amount of data variability, but have focused little on understanding the cause of such variability.
Daniels Pearce Melissa J. +1 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Proposal of a Transport Planning Model for the Removal of Quarry Stone Using a Simulation
Applied SciencesThis article describes a transport planning model which applies a simulation to support decision-making in quarry operations. The analysis of the transport system was used as input for creating the model and the subsequent research.
Janka Saderova +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source