Results 91 to 100 of about 1,895,947 (252)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Utility greedy discrete bit loading for interference limited multi-cell OFDM system [PDF]

, 2010
In this contribution we present the solution of the utility greedy discrete bit loading for interference limited multicell OFDM networks. Setting the utility as the sum of consumed power proportions, the algorithm follows greedy way to achieve the ...
Xuefen Yu, Su, Xinghui, Lv, Tiejun, Yu, Xuefen, Yang, Shaoshi, Li, Yonghua, Yonghua Li, Shaoshi Yang, Xinghui Su, Tiejun Lv   +9 more
core   +1 more source

Modeling of the internal structure of a spherical graphite inclusion in ductile cast iron and its behavior under loading

Литьë и металлургия
The goal of this work is to develop a finite element model of a spherical graphite inclusion in ductile cast iron, modeling the process of its destruction under bilateral compression and verification of models by performing compression experiments.A ...
A. I. Pokrovsky, I. V. Rafalski, P. E. Lushchyk   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Physical demands of collegiate basketball practice: a preliminary report on novel methods and metrics

Frontiers in Sports and Active Living
Knowing the specific physical demands of basketball players can provide useful information for clinical decision making when rehabilitating athletes following injury.
Peter Huynh, Samuel Guadagnino, Jessica Zendler, Jessica Zendler, Cristine Agresta   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Radiographic follow-up evaluation of sinus augmentation with deproteinized bovine bone and implant installation after loading

Indian Journal of Dental Research, 2010
Computed tomography (CT) has been used in diagnosis and implant treatment, and CT can be used to assess the dimensional stability of graft materials after maxillary sinus augmentation. A 50-year-old male patient was treated for the simultaneous placement
Park Jun-Beom
doaj