Results 51 to 60 of about 127,217 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The strain rate sensitive and anisotropic behavior of rare-earth magnesium alloy ZEK100 sheet

Journal of Magnesium and Alloys, 2023
To overcome the limitation in formability at room temperature, manufacturers have developed magnesium alloys with remarkable properties by adding rare-earth elements.
H. Wang, X. Sun, S. Kurukuri, M.J. Worswick, D.Y. Li, Y.H. Peng, P.D. Wu   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The loading direction dramatically affects the mechanical properties of the mouse tibia

Frontiers in Bioengineering and Biotechnology
Introduction: The in vivo tibial loading mouse model has been extensively used to evaluate bone adaptation in the tibia after mechanical loading treatment. However, there is a prevailing assumption that the load is applied axially to the tibia.
Saira Mary Farage-O’Reilly, Saira Mary Farage-O’Reilly, Saira Mary Farage-O’Reilly, Vee San Cheong, Vee San Cheong, Vee San Cheong, Edmund Pickering, Edmund Pickering, Peter Pivonka, Peter Pivonka, Ilaria Bellantuono, Ilaria Bellantuono, Visakan Kadirkamanathan, Visakan Kadirkamanathan, Enrico Dall’Ara, Enrico Dall’Ara, Enrico Dall’Ara   +16 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the inclined static loading of honeycomb re-entrant auxetics

, 2021
The present study unravels the deformation mechanisms observed during the static inclined compression of re-entrant honeycomb (RH) auxetic structure. A pushover Riks analysis is conducted by facing a rigid plate towards the structure at various angles. A
Javanbakht, Z, Hall, W, Dhari, RS
core   +1 more source

Anisotropic mechanical properties and cushioning effectiveness of spruce subjected to different direction loading

Materials Research Express
The arrayed microstructure of wood produced during growth results in anisotropic mechanical behavior at the macroscopic level. In order to assess the cushioning effectiveness of spruce, the microstructural models with regular hexagonal array cells along ...
Zexiong Zhang, Weizhou Zhong, Jiaxing Li, Jingrun Luo   +3 more
doaj   +1 more source

SIMULATION OF FRICTIONAL DISSIPATION UNDER BIAXIAL TANGENTIAL LOADING WITH THE METHOD OF DIMENSIONALITY REDUCTION

Facta Universitatis. Series: Mechanical Engineering, 2017
The paper is concerned with the contact between the elastic bodies subjected to a constant normal load and a varying tangential loading in two directions of the contact plane.
Andrey V. Dimaki, Roman Pohrt, Valentin L. Popov   +2 more
doaj   +1 more source