Results 61 to 70 of about 127,217 (298)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluation of the coefficient of lateral stress at rest of granular materials under repetitive loading conditions

Journal of Rock Mechanics and Geotechnical Engineering
Although the internal stress state of soils can be affected by repetitive loading, there are few studies evaluating the lateral stress (or K0) of soils under repetitive loading.
Heerym Han, Hyunwook Choo, Junghee Park
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The effect of dentinal fluid flow during loading in various directions - simulation of fluid- structure interaction

, 2013
Objectives This study uses a fluid–structure interaction (FSI) simulation to evaluate the fluid flow in a dental intrapulpal chamber induced by the deformation of the tooth structure during loading in various directions.
Chang, Chih-Han, Chuang, Shu-Fen, Su, Kuo-Chih, Ng, Eddie Yin-Kwee   +3 more
core   +1 more source

Damage coupling mechanical behaviors of 2D-SiC/SiC composite

Cailiao gongcheng, 2019
By using axial and off-axis loading tests with off-axis angle as 45°, the tensile, compressive and in-plane shear stress-strain behaviors along the fiber bundles directions of a 2D-SiC/SiC composite were obtained, and the damage coupling mechanical ...
GUO Hong-bao, XIE Jun
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Numerical study of AE and DRA methods in sandstone and granite in orthogonal loading directions

, 2012
The directional dependency of the acoustic emission (AE) and deformation rate analysis (DRA) methods was analyzed, based on the contact bond model in the two-dimensional particle flow code (PFC2D) in two types of rocks, the coarse-grained sandstone and ...
Ji-xun Zhang, Hai-jun Wang, Zhang, Ji-xun, Wang, Hai-jun, Ren, Xu-hua, Xu-hua Ren   +5 more
core   +1 more source

Left-right loading dependence of shock response of (111)//(112) Cu bicrystals: Deformation and spallation [PDF]

, 2012
We investigate with molecular dynamics the dynamic response of Cu bicrystals with a special asymmetric grain boundary (GB), (111)//(112)〈110〉, and its dependence on the loading directions. Shock loading is applied along the GB normal either from the left
Han, Weizhong, Luo, S. N., S. N. Luo, W. A. Goddard, An, Qi, D. L. Tonks, Germann, Timothy C., W. Z. Han, Q. An, Goddard III, William A., Tonks, D. L., T. C. Germann   +11 more
core   +2 more sources

STUDY ON LOAD MEASURING METHOD AND TEST OF THE PIN-SHAFT IN LOADER WORKING DEVICE

Jixie qiangdu, 2017
Based on the mechanical force model of the bucket on the working device of loader,the problem of the dynamic loading test was analyzed. The testing method considering pin-shaft lateral dynamic force was put forward,and the 3D forces in horizontal ...
WAN YiPin, SONG XuDing, YU LuPing, YUAN ZhengWen   +3 more
doaj