Results 111 to 120 of about 9,163,804 (344)
Molecular Partition Functions in Terms of Local Properties [PDF]
D. R. Herschbach+2 more
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
La Globalización y su Relación con la Contabilidad
En este artículo se presentan unos acercamientos iniciales sobre algunas de las tendencias argumentativas que se vienen desarrollando en torno de la globalización.
Aída Patricia Calvo V.
doaj
CYTOLOGICAL STUDIES IN ASSOCIATION WITH LOCAL INJECTIONS OF STREPTOKINASE-STREPTODORNASE INTO PATIENTS 1 [PDF]
Alan J. Johnson
openalex +1 more source
An all‐electron numerical method for solving the local density functional for polyatomic molecules
A method for accurate and efficient local density functional calculations (LDF) on molecules is described and presented with results. The method, Dmol for short, uses fast convergent three‐dimensional numerical integrations to calculate the matrix ...
B. Delley
semanticscholar +1 more source
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton+17 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
mRNA localization and local translation in neurons
The spatial and temporal regulation of gene expression in neurons is an important step in creating functional and structural neuronal networks. The complexity of neurons require differential expression of various proteins in different compartments. Highly polarised cells, such as neurons, respond rapidly to different external stimuli by changing their ...
openaire +5 more sources
On local controllability [PDF]
Let X, Y be real analytic vector fields on a real analytic n-dimensional manifold M. Consider a control system on M with dynamics described by \[(1)\qquad {{dx} / {dt}} = X(x(t)) + u(t)Y(x(t)),\quad x(0) = p,\]where an admissible control is Lebesgue measurable with values $| {u(t)} | \leqq 1$. The relationship between the map \[(2)\qquad (s_1 , \cdots ,
openaire +5 more sources
La laicidad problematizada. Su uso para pensar organismos estatales
Resumen La cuestión de los vínculos entre religión y política en general, y religiones y el Estado en particular, forma parte de la investigación social a nivel internacional y local.
María Pilar García Bossio
doaj +1 more source