Results 111 to 120 of about 9,163,804 (344)

Molecular Partition Functions in Terms of Local Properties [PDF]

open access: bronze, 1959
D. R. Herschbach   +2 more
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

La Globalización y su Relación con la Contabilidad

open access: yesRevista Facultad de Ciencias Económicas, 2006
En este artículo se presentan unos acercamientos iniciales sobre algunas de las tendencias argumentativas que se vienen desarrollando en torno de la globalización.
Aída Patricia Calvo V.
doaj  

An all‐electron numerical method for solving the local density functional for polyatomic molecules

open access: yes, 1990
A method for accurate and efficient local density functional calculations (LDF) on molecules is described and presented with results. The method, Dmol for short, uses fast convergent three‐dimensional numerical integrations to calculate the matrix ...
B. Delley
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

mRNA localization and local translation in neurons

open access: yesAIMS Neuroscience, 2020
The spatial and temporal regulation of gene expression in neurons is an important step in creating functional and structural neuronal networks. The complexity of neurons require differential expression of various proteins in different compartments. Highly polarised cells, such as neurons, respond rapidly to different external stimuli by changing their ...
openaire   +5 more sources

On local controllability [PDF]

open access: yes1981 20th IEEE Conference on Decision and Control including the Symposium on Adaptive Processes, 1976
Let X, Y be real analytic vector fields on a real analytic n-dimensional manifold M. Consider a control system on M with dynamics described by \[(1)\qquad {{dx} / {dt}} = X(x(t)) + u(t)Y(x(t)),\quad x(0) = p,\]where an admissible control is Lebesgue measurable with values $| {u(t)} | \leqq 1$. The relationship between the map \[(2)\qquad (s_1 , \cdots ,
openaire   +5 more sources

La laicidad problematizada. Su uso para pensar organismos estatales

open access: yesReligião e Sociedade
Resumen La cuestión de los vínculos entre religión y política en general, y religiones y el Estado en particular, forma parte de la investigación social a nivel internacional y local.
María Pilar García Bossio
doaj   +1 more source

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