Results 121 to 130 of about 9,163,804 (344)
La complejidad y la transformación de la educación
Conjeturas Sociologicas, 2021 La relación entre el sistema social, económico y político con el sistema educativo ha existido siempre, pero la observación de esa correspondencia a través de la mirada de la complejidad ha sido realizada solo desde tiempos recientes.
Olga C. Basora G.
doaj
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Journal of Coloproctology, 2012 BACKGROUND AND OBJECTIVES: Reducing postoperative pain in hemorrhoidectomy is still a challenge. This prospective, randomized, double-blind study was conducted to compare bilateral pudendal blockade with peripheral nerve stimulator to relieve ...
Luiz Eduardo Imbelloni +2 more
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Relationship Between a Range of Tissue Temperature and Local Oxygen Uptake in the Human Forearm. I. Changes Observed Under Resting Conditions12 [PDF]
, 1958 David I. Abramson +5 more
openalex +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Local Homology and Local Cohomology
, 2004 Let $(R, {\frak m})$ be a local ring, $I$ a proper ideal of $R$ and $M$ a finitely generated $R$-module of dimension $d$. We discuss the local homology modules of $H^d_I(M)$. When $M$ is Cohen-Macaulay, it is proved that $H^d_{\frak m}(M)$ is co-Cohen-Macaulay of N.dimension $d$ and $H^{\underline{x}}_d(H^d_{\frak m}(M))\cong\hat{M}$ where $\underline ...
openaire +3 more sources
Simulation thermique des locaux en contact avec le sol par voie d’analyse modale
Revue des Énergies Renouvelables, 2013 Nous présentons dans ce travail un modèle de simulation thermique des bâtiments en contact avec le sol. Il permet l’étude du comportement thermique des éléments de l’enveloppe, du plancher bas en contact avec le sol et enfin le couplage entre les ...
A. Zairi, A. Mokhtari
doaj
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source