Results 51 to 60 of about 9,205,514 (369)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

MTLDesc: Looking Wider to Describe Better [PDF]

arXiv, 2022
Limited by the locality of convolutional neural networks, most existing local features description methods only learn local descriptors with local information and lack awareness of global and surrounding spatial context. In this work, we focus on making local descriptors "look wider to describe better" by learning local Descriptors with More Than just ...
arxiv  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Translation as a New Tool for Philosophizing the Dialectic between the National and the Global in the History of Revolutions: Germanizing the Bible, and Sinicizing Marxist Internationalism

Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2020
This paper uses Martin Luther and Mao Zedong's translation strategies to philosophize anew the dialectic between the national and the global in the history of revolutions.
Sinkwan Cheng
doaj  

Maximally Recoverable Codes with Hierarchical Locality: Constructions and Field-Size Bounds [PDF]

arXiv, 2021
Maximally recoverable codes are a class of codes which recover from all potentially recoverable erasure patterns given the locality constraints of the code. In earlier works, these codes have been studied in the context of codes with locality. The notion of locality has been extended to hierarchical locality, which allows for locality to gradually ...
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Local Irregularity Conjecture for 2-multigraphs versus cacti [PDF]

arXiv, 2022
A multigraph is locally irregular if the degrees of the end-vertices of every multiedge are distinct. The locally irregular coloring is an edge coloring of a multigraph $G$ such that every color induces a locally irregular submultigraph of $G$. A locally irregular colorable multigraph $G$ is any multigraph which admits a locally irregular coloring.
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Local Television and Local News

Communications, 1997
The question addressed in this article is whether there there is anything local and alternative about local television news in Denmark. Many stations claim local news to be of particular importance for their profile and the primary legitimation of local television.
Prehn, Ole, Jauert, Per
openaire   +3 more sources

PCA-SIFT: a more distinctive representation for local image descriptors

Proceedings of the 2004 IEEE Computer Society Conference on Computer Vision and Pattern Recognition, 2004. CVPR 2004., 2004
Stable local feature detection and representation is a fundamental component of many image registration and object recognition algorithms. Mikolajczyk and Schmid (June 2003) recently evaluated a variety of approaches and identified the SIFT [D. G.
Yan Ke, R. Sukthankar
semanticscholar   +1 more source