Results 141 to 150 of about 1,104,255 (313)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Global emergency, local action: safeguarding Pakistan from Mpox

Journal of the Pakistan Medical Association
Madam, Monkeypox (Mpox) is a zoonotic viral disease that the World Health Organization declared a public health emergency of international concern he following a surge in Africa and spread to neighbouring countries.
Uswa Hasana, Wahhaj Munir, Adil Khan
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Coordinated support for local action: Modeling strategies to facilitate behavior adoption in urban-poor communities of Liberia for sustained COVID-19 suppression. [PDF]

Epidemics, 2021
Skrip LA, Fallah MP, Bedson J, Hébert-Dufresne L, Althouse BM.   +4 more
europepmc   +1 more source

Enabling equitable collective action and policy change for poverty reduction and improved natural resource management in the Eastern African highlands: [PDF]

"The role of local and external institutions in natural resource management (NRM) is gaining attention in the literature, fostering greater understanding of the relationship between collective action and poverty, collective action and equity, and the ...
Ayele, Shenkut, Alinyo, Francis, Begashaw, Leulseged, Aberra, Kassahun, Chemangeni, Awadh, Taye, Hailemichael, Bedane, Kiflu, Mazengia, Waga, Nyangas, Simon, Tirwomwe, Wilberforce, Mekonnen, Ashenafi, Tanui, Joseph, Admassu, Zenebe, Jotte Zewdie, German, Laura, Tolera, Tessema, Cheptegei, William, Tsegaye, Mesfin   +17 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

How Local Stakeholders are Implementing the Deferred Action for Childhood Arrivals Program

, 2016
In June 2012, President Obama instituted the Deferred Action for Childhood Arrivals program, which suspended deportations and authorized work permits for an estimated 1.76 million eligible young undocumented immigrants.
Gleeson, Shannon, de Graauw, Els
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Local action plan to promote access to the health system by indigenous Venezuelans from the Warao ethnic group in Manaus, Brazil: Analysis of the plan´s development, experiences, and impact through a mixed-methods study (2020). [PDF]

PLoS One, 2021
de Jezus SV, Ilha da Silva A, Alexandre Arcêncio R, de Faria Marcos Terena N, Dos Santos Pinheiro J, Souza Sacramento D, de Souza Silva Freitas P, Carminati Siqueira P, Mocelin HJS, Maria Silva Araújo V, da Silva Lima R, Nascimento do Prado T, Maia Martins Sales C, Noia Maciel EL.   +13 more
europepmc   +1 more source