Results 71 to 80 of about 496,747 (294)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Global versus local shocks in micro price dynamics [PDF]
A number of recent papers point to the importance of distinguishing between the price reaction to micro and macro shocks in order to reconcile the volatility of individual prices with the observed persistence of aggregate inflation.
Zachariadis, M., Andrade, P.
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Topographies of Local Public Spheres on Social Media: The Scope of Issues and Interactions
International Journal of Communication, 2021 Following calls for a spatial turn in communication studies, we investigate the reach and topography of Twitter communication in two case studies of Berlin and Jerusalem.
Barbara Pfetsch +5 more
doaj
Attention to local health burden and the global disparity of health research.
PLoS ONE, 2014 Most studies on global health inequality consider unequal health care and socio-economic conditions but neglect inequality in the production of health knowledge relevant to addressing disease burden.
James A Evans +2 more
doaj +1 more source
The FASEB Journal, 2014 Ryanodine receptors (RyR) are calcium‐sensitive ion channels in the sarcoplasmic reticulum (SR) membrane, and are important effectors in arterial smooth muscle excitation‐contraction (EC) coupling. While three different RyR isoforms are expressed in arterial smooth muscle cells (SMCs), the relative contribution of each RyR isoform ...
Mario Kassmann +4 more
openaire +1 more source
Majority voting on restricted domains [PDF]
, 2010 In judgment aggregation, unlike preference aggregation, not much is known about domain restrictions that guarantee consistent majority outcomes. We introduce several conditions on individual judgments sufficient for consistent majority judgments.
List, C. +3 more
core +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Rekayasa Pendidikan Agama Islam di Daerah Minoritas Muslim
Tadris: Jurnal Keguruan dan Ilmu Tarbiyah, 2016 Islamic education research nowadays still becomes the main concern from majority of Muslim as the development of Islamic education with the high awareness of all its members.
Rabiatul Adawiyah, Wan Zamaluddin Z
doaj +1 more source