Results 81 to 90 of about 496,747 (294)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Marginalised millennials: Conversation or conversion towards a Christian lifestyle in South Africa?

HTS Teologiese Studies/Theological Studies, 2018
The World Council of Churches’ statement prepared by the Commission on World Mission and Evangelism, Together Towards Life: Mission and Evangelism in Changing Landscapes, states that mission from the margins calls for an understanding of the complexities
Johannes J. Knoetze
doaj   +1 more source

Global Value Chains, Technology Transfer and Local Firm Upgrading in Non-OECD Countries [PDF]

The productivity and competitiveness of local firms in non-OECD countries depends as much on technological capacities and successful upgrading as in industrialized countries.
Juliane Brach, Robert Kappel
core  

GLOBAL AND LOCAL ELECTROPHILIC POWER INDICES FOR THEORETICAL STUDY OF THE CHEMICAL REACTIVITY: APPLICATION TO α,β-UNSATURATED CARBONYL DERIVATIVES

, 2017
In this study two new global descriptors for chemical reactivity are proposed, namely the electrophilic power and nucleophilic power. These have been developed by performing the normalization of the local electrophilic power and local nucleophilic power ...
Said F. Figueredo (12702882), Francisco Torres (2986854), Manuel S. Páez (12702885)   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Detection of Local and Global Outliers in Spatial Data [PDF]

, 2013
Spatial data are characterized by statistical units, with known geographical positions, on which non spatial attributes are measured. Two types of atypical observations can be defined: global and/or local outliers.
Ernst, Marie, Haesbroeck, Gentiane
core   +1 more source

Deep Graph Clustering Framework Based on Confidence-Guided Graph Enhancement and Dual-Negative Sample Contrastive Learning

Entropy
Attributed graph clustering partitions nodes in an unsupervised manner by leveraging graph topology and node attributes. Existing deep methods face challenges including local structural bias, high noise in unsupervised graph editing, and insufficient ...
Qiuming Wang, Sheng Zhang, Bing Wu, Jiangnan Zhou, Chennan Wu, Yirong Zeng, Ka Sun, Chang Liu   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source