Results 21 to 30 of about 252,842 (294)

Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats

Frontiers in Neural Circuits, 2022
BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased
Mingyue Zhang, Mingyue Zhang, Yali Chen, Yali Chen, Jin Liu, Jin Liu, Yaoxin Yang, Yaoxin Yang, Rurong Wang, Donghang Zhang, Donghang Zhang, Tao Zhu   +11 more
doaj   +1 more source

The Thermodynamics of General and Local Anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare, Sasse-Middelhoff, Henrike, Heimburg, Thomas   +2 more
openaire   +5 more sources

INTRAVENOUS LOCAL ANESTHESIA [PDF]

Journal of the American Medical Association, 1912
In searching for a method to avoid the difficulties of nerve-blocking anesthesia, Bier 1 developed the idea of Venenanasthesie which he reported at the thirty-seventh German Surgical Congress, in 1908. In 1909, he reported a series of 134 cases and gave in detail the technic of the method. 2 The anesthetizing solution is injected into the veins, in a
openaire   +3 more sources

Electroencephalographic depression after abruptly increasing partial pressure of end-tidal carbon dioxide: a case series

BMC Anesthesiology
Background Prolonged electroencephalographic depression during surgery is associated with poor outcomes for patients. However, the published literature on electroencephalographic depression caused by a sudden increase in the partial pressure of end-tidal
Shikuo Li, Yuyi Zhao, Qifeng Wang, Xuehan Li, Chao Chen, Yunxia Zuo   +5 more
doaj   +1 more source

Dexmedetomidine with different concentrations added to local anesthetics in erector spinae plane block: a meta-analysis of randomized controlled trials

Frontiers in Medicine
BackgroundDexmedetomidine has been used as a perineural local anesthetic (LA) adjuvant to facilitate the potency of erector spinal plane block (ESPB). This quantitative review aimed to evaluate whether perineural dexmedetomidine for ESPB can improve the ...
Qian Li, Qian Li, Yaoxin Yang, Yaoxin Yang, Yu Leng, Yu Leng, Xiaowei Yin, Jin Liu, Cheng Zhou   +8 more
doaj   +1 more source

Anesthesia methods for full-endoscopic lumbar discectomy: a review

Frontiers in Medicine, 2023
Full-endoscopic lumbar discectomy under local anesthesia is major trends for the treatment of lumbar disc herniation in spine minimally invasive surgery.
Bin Zheng, Chen Guo, Shuai Xu, Haoyuan Li, Yonghao Wu, Haiying Liu   +5 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Rapid quantification and PK-PD modeling of rocuronium bromide in beagles using portable mass spectrometer

Frontiers in Veterinary Science
Monitoring rocuronium bromide (Rocur) concentrations is crucial for assessing muscle relaxation in clinical anesthesia. However, no suitable instruments are currently available. This study explores the application of a portable mass spectrometer (MS) for
Xiaoxiao Li, Xiaoxiao Li, Pan Chang, Pan Chang, Xing Liu, Xing Liu, Deying Gong, Deying Gong, Wensheng Zhang, Wensheng Zhang   +9 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source