Results 31 to 40 of about 295,501 (266)

The Prevalence of Advance Directives and Its Moderators Among Community People, Acutely and Chronically Ill Patients: A Systematic Review and Meta-Analysis

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Advance Directives (ADs) are essential in end-of-life care, enabling individuals to retain autonomy when they can no longer make decisions. However, data on ADs prevalence and influencing factors in different populations (acutely ill, chronically ill ...
Danila Valenti MD, Giulia Bortolotti, Federico Moro MD, Silvia Cardini MD, Silvia Cavagna MD, Marco Tartaglione MD, Davide Allegri MSc, Fabrizio Moggia MSN, Federico Semeraro MD, Lorenzo Gamberini MD   +9 more
doaj   +1 more source

Rapid quantification and validation of etomidate and dexmedetomidine blood concentrations in rats using a novel portable mass spectrometer

Frontiers in Veterinary Science
In clinical anesthesia, precise dosing depends on feedback from blood drug concentrations. However, rapid tools for measuring these concentrations are currently limited.
Sicheng Liu, Sicheng Liu, Xiaoxiao Li, Xiaoxiao Li, Deying Gong, Yanhua Huang, Wensheng Zhang, Wensheng Zhang   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

Acta Pharmaceutica Sinica B
While transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety.
Yi Zhao, Wei Ai, Jieyu Zhao, Xi Yang, Wencheng Liu, Yaru Ma, Jianrui Mou, Ao Hai, Ran Ji, Yu Gan, Zhuang Miao, Shilong Hu, Zhenbo Huang, Jin Liu, Xianggen Liu, Jun Yang, Bowen Ke   +16 more
doaj   +1 more source

Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs

Frontiers in Pharmacology, 2021
Background: ET-26 hydrochloride (ET-26HCl), a class 1 new drug, was developed to reserve the advantages of etomidate with a mild adrenocortical inhibition.Purpose: this study was to evaluate the potential adverse effects on the cardiovascular system of ...
YuJun Zhang, YuJun Zhang, YuJun Zhang, YingYing Jiang, YingYing Jiang, YingYing Jiang, Pan Chang, Pan Chang, Pan Chang, Yi Kang, Yi Kang, DeYing Gong, DeYing Gong, Jin Liu, Jin Liu, Jin Liu, WenSheng Zhang, WenSheng Zhang   +17 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

miRNAs-neutrophil axis: novel insights into acute lung injury and chronic inflammatory lung diseases

Frontiers in Immunology
Acute lung injury (ALI) and chronic inflammatory lung disorders constitute significant clinical burdens with high morbidity and mortality. Neutrophils are commonly found in lung diseases and serve as pivotal effector cells governing pulmonary ...
Xingning Lai, Xingning Lai, Jie Zhong, Jie Zhong, Chenxi Liao, Chenxi Liao, Baojiang Chen, Baojiang Chen, Wensheng Zhang, Wensheng Zhang, Ren Liao, Ren Liao   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Rapid quantification and PK-PD modeling of rocuronium bromide in beagles using portable mass spectrometer

Frontiers in Veterinary Science
Monitoring rocuronium bromide (Rocur) concentrations is crucial for assessing muscle relaxation in clinical anesthesia. However, no suitable instruments are currently available. This study explores the application of a portable mass spectrometer (MS) for
Xiaoxiao Li, Xiaoxiao Li, Pan Chang, Pan Chang, Xing Liu, Xing Liu, Deying Gong, Deying Gong, Wensheng Zhang, Wensheng Zhang   +9 more
doaj   +1 more source