Results 21 to 30 of about 283,087 (266)

The Prevalence of Advance Directives and Its Moderators Among Community People, Acutely and Chronically Ill Patients: A Systematic Review and Meta-Analysis

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Advance Directives (ADs) are essential in end-of-life care, enabling individuals to retain autonomy when they can no longer make decisions. However, data on ADs prevalence and influencing factors in different populations (acutely ill, chronically ill ...
Danila Valenti MD, Giulia Bortolotti, Federico Moro MD, Silvia Cardini MD, Silvia Cavagna MD, Marco Tartaglione MD, Davide Allegri MSc, Fabrizio Moggia MSN, Federico Semeraro MD, Lorenzo Gamberini MD   +9 more
doaj   +1 more source

Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats

Frontiers in Veterinary Science
IntroductionThe preclinical phase of innovative drug research and development involves a comprehensive assessment of multiple variables that may influence therapeutic outcomes and safety profiles.
Sicheng Liu, Sicheng Liu, Deying Gong, Xiaoxiao Li, Xiaoxiao Li, Feng Qiu, Feng Qiu, Wensheng Zhang, Wensheng Zhang   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes

Acta Pharmaceutica Sinica B
While transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety.
Yi Zhao, Wei Ai, Jieyu Zhao, Xi Yang, Wencheng Liu, Yaru Ma, Jianrui Mou, Ao Hai, Ran Ji, Yu Gan, Zhuang Miao, Shilong Hu, Zhenbo Huang, Jin Liu, Xianggen Liu, Jun Yang, Bowen Ke   +16 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs

Frontiers in Pharmacology, 2021
Background: ET-26 hydrochloride (ET-26HCl), a class 1 new drug, was developed to reserve the advantages of etomidate with a mild adrenocortical inhibition.Purpose: this study was to evaluate the potential adverse effects on the cardiovascular system of ...
YuJun Zhang, YuJun Zhang, YuJun Zhang, YingYing Jiang, YingYing Jiang, YingYing Jiang, Pan Chang, Pan Chang, Pan Chang, Yi Kang, Yi Kang, DeYing Gong, DeYing Gong, Jin Liu, Jin Liu, Jin Liu, WenSheng Zhang, WenSheng Zhang   +17 more
doaj   +1 more source

INTRAVENOUS LOCAL ANESTHESIA [PDF]

Journal of the American Medical Association, 1912
In searching for a method to avoid the difficulties of nerve-blocking anesthesia, Bier 1 developed the idea of Venenanasthesie which he reported at the thirty-seventh German Surgical Congress, in 1908. In 1909, he reported a series of 134 cases and gave in detail the technic of the method. 2 The anesthetizing solution is injected into the veins, in a
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

miRNAs-neutrophil axis: novel insights into acute lung injury and chronic inflammatory lung diseases

Frontiers in Immunology
Acute lung injury (ALI) and chronic inflammatory lung disorders constitute significant clinical burdens with high morbidity and mortality. Neutrophils are commonly found in lung diseases and serve as pivotal effector cells governing pulmonary ...
Xingning Lai, Xingning Lai, Jie Zhong, Jie Zhong, Chenxi Liao, Chenxi Liao, Baojiang Chen, Baojiang Chen, Wensheng Zhang, Wensheng Zhang, Ren Liao, Ren Liao   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source