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Frontiers in Microbiology, 2023 BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear.
Mengchan Su +8 more
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Computer-controlled local anesthetic delivery for painless anesthesia: a literature review [PDF]
, 2016 Local anesthesia is administered to reduce pain during dental treatments, but may itself cause pain and contribute to increased dental fear. Computer-controlled local anesthetic delivery (CCLAD) is one the method to reduce patient pain during local ...
곽은정 +5 more
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, 2022 : This research compared the student-to-student (STS) model of injection as a default teaching strategy for dentistry students and the non-classmate-as-patient model of injection in helping dental students acquire or increase their level of empathy. This
Erlyn A. Sana +2 more
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Local anesthesia and midazolam versus spinal anesthesia in ambulatory pilonidal surgery
, 2003 Study objective: To evaluate two anesthetic techniques, namely, local anesthesia with sedation, and spinal anesthesia, with respect to recovery times, postoperative side effects, pain scores, patient satisfaction, and hospital costs for ambulatory ...
Erdem, Ergün +2 more
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FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Frontiers in Veterinary ScienceIntroductionThe preclinical phase of innovative drug research and development involves a comprehensive assessment of multiple variables that may influence therapeutic outcomes and safety profiles.
Sicheng Liu +8 more
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Frontiers in Pharmacology, 2021 Background: ET-26 hydrochloride (ET-26HCl), a class 1 new drug, was developed to reserve the advantages of etomidate with a mild adrenocortical inhibition.Purpose: this study was to evaluate the potential adverse effects on the cardiovascular system of ...
YuJun Zhang +17 more
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INTRAVENOUS LOCAL ANESTHESIA [PDF]
Journal of the American Medical Association, 1912 In searching for a method to avoid the difficulties of nerve-blocking anesthesia, Bier 1 developed the idea of Venenanasthesie which he reported at the thirty-seventh German Surgical Congress, in 1908. In 1909, he reported a series of 134 cases and gave in detail the technic of the method. 2 The anesthetizing solution is injected into the veins, in a
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Acta Pharmaceutica Sinica BWhile transient perioperative side effects of intravenous anesthetics are often tolerated, the persistent postoperative sequelae resulting from drug accumulation pose a critical threat to patient safety.
Yi Zhao +16 more
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